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Innovative tissue engineering strategies to repair spinal disc herniation

Mary Ann Liebert, Inc./Genetic Engineering News

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BioResearch Open Access is a peer-reviewed open access journal led by Editor-in-Chief Robert Lanza, MD, Chief Scientific Officer, Ocata Therapeutics Headquarters, and Editor Jane Taylor, PhD. The Journal... view more

Credit: ©Mary Ann Liebert, Inc., publishers

New Rochelle, NY, December 8, 2015 --New therapeutic approaches to repair herniated discs in the lumbar spine using novel tissue engineering and regenerative medicine strategies have shown promising outcomes in preclinical studies and target the underlying problem of disc injury or instability, unlike current nonsurgical and surgical treatments. Though these emerging biological repair methods still face challenges as they advance to and through clinical testing in patients, they may be able to offer significant pain reduction and restore flexibility and motion of the spine, according to a Review article published in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available to download on the BioResearch Open Access website.

In "Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation," Grace O'Connell, PhD, University of California (UC), Berkeley, and J. Kent Leach and Eric Klineberg, UC, Davis and UC, Davis Medical Center, describe recent progress in clinical studies of cell-based tissue engineering approaches combined with materials-based advances. The authors provide a comprehensive review of the literature, clearly presenting the features of clinical disc herniation, the mechanical properties of intervertebral discs and how they relate to the stability, flexibility, and load-bearing functions of the spine, and the latest research on the scope and promise of tissue engineering approaches to repair or replace disc tissue.

"This review provides an excellent up-to-date source of information on the role tissue engineering and regenerative medicine strategies can play in disc herniation repair," says BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland.

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About the Journal

BioResearch Open Access is a peer-reviewed open access journal led by Editor-in-Chief Robert Lanza, MD, Chief Scientific Officer, Ocata Therapeutics Headquarters, and Editor Jane Taylor, PhD. The Journal provides a new rapid-publication forum for a broad range of scientific topics including molecular and cellular biology, tissue engineering and biomaterials, bioengineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, biochemistry, virology, microbiology, and neuroscience. All articles are published within 4 weeks of acceptance and are fully open access and posted on PubMed Central. All journal content is available on the BioResearch Open Access website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many areas of science and biomedical research, including DNA and Cell Biology, Tissue Engineering, Stem Cells and Development, Human Gene Therapy, and AIDS Research and Human Retroviruses. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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