Public Release: 

Folic Acid, Vitamin B12, and One-Carbon Metabolism

Federation of American Societies for Experimental Biology

Bethesda, MD - One-carbon metabolism and related dietary factors (folic acid and vitamin B12, as well as vitamin B6, choline, riboflavin, methionine, serine, cysteine, and others) play important roles in a vast array of essential physiological functions. Disruptions of one-carbon metabolism due to dietary, pharmacological, environmental, and genetic factors impact most of the major health issues of our time, including vascular disease, cancer, neurodegenerative disease (Alzheimer's disease and dementia, Parkinson's disease), birth defects, and comorbidities associated with obesity and diabetes such as renal disease.

This conference has embraced an integrative philosophy that brings together basic researchers, physician scientists, and policy makers to share cutting edge research and to discuss its ramifications for health at both the personal and population levels. For 2016, in addition to updates on new findings related to the fundamental biochemistry of folates, B12, and one-carbon metabolism, session topics will focus on 1) the intersection of one-carbon metabolism and lipid metabolism, 2) the emerging roles of factors such as hydrogen sulfide and choline-related metabolites in health, 3) the effects of B vitamin deficiencies and excesses during in utero and post-natal development on adult phenotypes, 4) the influence of one-carbon metabolism on the brain in development and aging, 5) new developments in the area of cancer therapeutics and drug delivery, and 6) the potential impact of excess folic acid exposure on health. Conference attendees can expect thought-provoking oral communications from established leaders in the field, ample opportunities for students and post-doctoral trainees to present their work in both oral and poster sessions, and formal and informal opportunities to exchange ideas and establish new collaborations.

FASEB has announced a total of 36 Science Research Conferences (SRC) in 2016. Registration opens January 17, 2016. For more information about an SRC, view preliminary programs, or find a listing of all our 2016 SRCs, please visit


Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes. In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff at Proposal guidelines can be found at

FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

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