Public Release: 

Changes in brain connectivity protect against developing bipolar disorder

The Mount Sinai Hospital / Mount Sinai School of Medicine

Naturally occurring changes in brain wiring can help patients at high genetic risk of developing bipolar disorder avert the onset of the illness, according to a new study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Translational Psychiatry. The study's findings open up new avenues for researchers to explore ways the brain can prevent disease expression, also known as resilience, with the hope of developing better treatments.

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes fluctuations in patients' mood, energy, activity levels and the ability to carry out day-to-day tasks. Bipolar disorder is highly heritable, meaning that people with a parent or sibling with bipolar disorder have a much greater risk of developing the illness, compared with individuals with no family history.

Researchers used functional magnetic resonance imaging (MRI) to map the connectivity patterns in the brains of three groups: patients with bipolar disorder, their siblings who did not develop the illness (resilient siblings), and unrelated healthy individuals. While having their brains scanned, each participant was asked to perform an emotional and a non-emotional task that taps into two different aspects of brain function known to be affected by bipolar disorder. The resilient siblings and the patients showed similar abnormalities in the connectivity of brain networks involved in emotional processing. However, the resilient siblings showed additional changes in brain wiring within these networks.

"The ability of the siblings to rewire their brain networks means they have adaptive neuroplasticity that may help them avoid the disease even though they still carry the genetic scar of bipolar disorder when they process emotional information," said Sophia Frangou, MD, PhD, Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai and lead author of the study. Dr. Frangou's ongoing research uses neuroimaging to study how differences in brain wiring can either increase or decrease the likelihood of developing mental health problems.

"A family history remains the greatest risk factor for developing bipolar disorder and while we often focus on risk, we may forget that the majority of those who fall into this category remain well," said Dr. Frangou. "Looking for biological mechanisms that can protect against illness opens up a completely new direction for developing new treatments. Our research should give people hope that even though mental illness runs in families, it is possible to beat the odds at the genetic lottery."


The study was supported by awards from the National Institute of Mental Health and the Brain & Behavior Research Foundation. Additional collaborators include researchers from King's College London and Imperial College London, UK.

About the Mount Sinai Health System

The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services--from community-based facilities to tertiary and quaternary care.

The System includes approximately 6,100 primary and specialty care physicians; 12 joint-venture ambulatory surgery centers; more than 140 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. Physicians are affiliated with the renowned Icahn School of Medicine at Mount Sinai, which is ranked among the highest in the nation in National Institutes of Health funding per investigator. The Mount Sinai Hospital is ranked as one of the nation's top 10 hospitals in Geriatrics, Cardiology/Heart Surgery, and Gastroenterology, and is in the top 25 in five other specialties in the 2015-2016 "Best Hospitals" issue of U.S. News & World Report. Mount Sinai's Kravis Children's Hospital also is ranked in seven out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 11th nationally for Ophthalmology, while Mount Sinai Beth Israel is ranked regionally.

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