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For older adults, serious depression symptoms increase risk for stroke and heart disease

American Geriatrics Society

Depression and its symptoms increase as people age, and have been linked to heart disease and stroke in both middle-aged and older adults. But whether depression and its symptoms are risk factors for these two dangerous conditions has been unclear.

In a new study published in the Journal of the American Geriatrics Society, researchers set out to learn more about whether depression or its symptoms affect heart disease and stroke in older adults.

The researchers studied 7,313 older adults selected from the election rolls of three large French cities between 1999 and 2001. None of the participants had a history of heart disease, stroke, or dementia at the start of the study. Researchers conducted face-to-face interviews with the participants when the study began, and checked them again three times--two years, four years, and seven years after their initial interview. In addition, researchers tested the participants' mental health status, blood sugar, and cholesterol levels, and asked them questions about medical history and medications. In addition, the researchers determined whether or not the participants had symptoms of depression.

At the beginning of the study, nearly 30 percent of the women and 15 percent of the men (23 percent of all participants in total) had high levels of depressive symptoms. The researchers discovered that about 40 percent of people with high levels of depressive symptoms "recovered" and the same amount of people developed new depression symptoms at each follow-up visit. During all study visits, fewer than 10 percent of the participants were taking medications for depression.

The researchers discovered that adults 65-years-old and older who had high levels of depressive symptoms on one, two, three, or four occasions during the study had 15 percent, 32 percent, 52 percent, and 75 percent greater risk, respectively, for experiencing heart disease or stroke events over the 10 years of the study. As a result, the researchers concluded that depression could be a risk factor for heart disease or stroke. They suggested that physicians pay close attention to symptoms of depression in older adults under care.


This summery is from "High Level of Depressive Symptoms at Repeated Study Visits and the Risk of Coronary Heart Disease and Stroke over 10 Years in Older Adults: The Three-City Study." It appears online ahead of print in the January 2016 issue of the Journal of the American Geriatrics Society. The study authors are Renaud Péquignot, MD, MPH; Carole Dufouil, PhD; Christof Prugger, MD, PhD; Karine Pérès, PhD; Sylvaine Artero, PhD; Christophe Tzourio, MD, PhD; and Jean-Philippe Empana, MD, PhD.

About the Health in Aging Foundation

This research summary was developed as a public education tool by the Health in Aging Foundation. The Foundation is a national non-profit established in 1999 by the American Geriatrics Society to bring the knowledge and expertise of geriatrics healthcare professionals to the public. We are committed to ensuring that people are empowered to advocate for high-quality care by providing them with trustworthy information and reliable resources. Last year, we reached nearly 1 million people with our resources through We also help nurture current and future geriatrics leaders by supporting opportunities to attend educational events and increase exposure to principles of excellence on caring for older adults. For more information or to support the Foundation's work, visit

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