Exposure to alcohol before birth might impair kidney blood flow in adulthood and heighten neurological problems caused by a stroke, according to an animal study presented at the American Stroke Association's International Stroke Conference 2016.
A research team from Texas A&M Health Science Center, College of Medicine, administered ethanol to six pregnant mice twice daily for four days, from gestational day 12 through 15, and administered water to six other pregnant mice. At 12 days of gestation, the mice were in a stage of pregnancy comparable to late in the first trimester for humans, researchers said.
Using ultrasound testing, the team measured blood flow in both male and female offspring of the mice at 3 months of age, a period equivalent to young adulthood in humans. Blood flow analysis showed evidence for increased arterial resistance within the kidneys -- a sign of possible early onset renal hypertension -- in the male offspring that were exposed to alcohol before birth.
Researchers then assessed neurological damage caused by stroke in both male and female offspring and found greater levels of impairment in the six female and six male mice that had fetal alcohol exposure, compared with the dozen that were not exposed to alcohol.
Measurements of the stroke-damaged area of the brain were correlated to scores on neurological testing in the females, but not the males, with fetal alcohol exposure. "The finding indicates that in mice exposed to alcohol before birth, sex appears to play some role in whether the volume of damaged tissue in the brain correlates with functional and neurological impairment," said lead researcher Shameena Bake, Ph.D., and assistant professor at Texas A&M Health Science Center in Bryan, Texas.
Any available multimedia related to these tips are on the right column of this link http://newsroom.
Future vaccine may help lower blood pressure long-term
Gut bacteria may impact body weight, fat and good cholesterol levels
Understanding stroke risk factors
Join the AHA/ASA's Support Network to talk with others going through similar journeys including depression after stroke.
Follow news from the American Stroke Association's International Stroke Conference 2016 via Twitter: @HeartNews #ISC16.
Statements and conclusions of study authors that are presented at American Stroke Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.