An analysis of scientific reports and comments on the health effects of a salty diet reveals a polarization between those supportive of the hypothesis that population-wide reduction of salt intake is associated with better health and those that were not. In all, 54 percent were supportive of the hypothesis; 33 percent, not supportive; and 13 percent inconclusive.
The new article in the International Journal of Epidemiology is co-authored by Ludovic Trinquart, Columbia University Epidemiology Merit Fellow at the Mailman School of Public Health; David Johns, a doctoral student in Sociomedical Sciences at the Mailman School of Public Health and an affiliate of the Data & Society Research Institute; and Sandro Galea, dean of the Boston University School of Public Health and adjunct professor of Epidemiology at the Mailman School.
The researchers systematically reviewed 269 academic reports published between 1979 and 2014, including primary studies, meta-analyses, clinical guidelines, consensus statements, comments, letters, and narrative reviews. Each was classified according to whether it supported or refuted the link between reduced sodium intake and lower rates of heart disease, stroke, and death. More than half of the reports were published since 2011--suggesting an increasing level of interest in the question, even if there was no emerging consensus.
A citation analysis found papers on either side of the hypothesis were more likely to cite reports that drew a similar conclusion than to cite reports drawing a different conclusion. Dominating the literature were a small number of influential papers that presented strong evidence for and against.
"There are two almost distinct bodies of scholarship--one supporting and one opposing the claim that salt reduction in populations will improve clinical outcomes," says Johns. "Each is driven by a few prolific authors who tend to cite other researchers who share their point of view, with little apparent collaboration between the two 'sides.'"
"We pay quite a bit of attention to financial bias in our work," says Galea. "We seldom pay attention, however, to how long-held beliefs bias the questions we ask and the results we publish, even as new data become available."
An analysis of systemic reviews revealed very little consistency in the selection of primary studies. If a primary study was selected by a review, the chance that another review would select the same study was less than a third. The finding points to uncertainty and disagreement about what should count as evidence, the authors argue. Moreover, choices about which studies to cite as primary evidence directly influenced the conclusions of systematic reviews.
Even while the scientific debate over salt continues, public health officials, from the local to the global level, have enacted policies to lower consumption. World Health Organization guidelines recommend limiting salt intake. In December 2015, New York City became the first U.S. city to require chain restaurants to label foods high in sodium.
"Decision-makers often must choose a course of action in the face of conflicting, uncertain evidence," says Trinquart. "Both the misuse of uncertainty and the exaggeration of certainty can shape the outcomes of public health decision-making processes."
The authors say the citation analysis method used in the study represents a new way of understanding the relationships between academic research papers and authors. In the future, the same method could be applied to other topics, including controversial issues such as e-cigarettes as well as topics on which there is greater agreement.
About Columbia University's Mailman School of Public Health
Founded in 1922, Columbia University's Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Mailman School is the third largest recipient of NIH grants among schools of public health. Its over 450 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as preventing infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,300 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Mailman School is also home to numerous world-renowned research centers including ICAP (formerly the International Center for AIDS Care and Treatment Programs) and the Center for Infection and Immunity. For more information, please visit www.mailman.columbia.edu