Diagnosing disease can be highly technical, costly and time-consuming, which are all challenges that become particularly problematic in low-income and remote locations. Now scientists are reporting in the journal ACS Applied Materials & Interfaces a new way to repurpose portable glucose monitors to harness these simple devices' practicality and low cost for the detection of other diseases.
There are many benefits to diagnosing disease quickly. Treatment can start earlier, which can lead to better outcomes. It saves time and money. It can also minimize patients' anxiety as they wait for results. But rapid diagnoses aren't always possible using current technology. The personal glucose monitor, however, is one medical testing device that can deliver results rapidly. Building on its success, scientists have started repurposing it to test for other substances, such as cocaine or Salmonella bacteria in milk. But the methods they used so far required complicated and time-consuming steps. Chaoyong James Yang and colleagues wanted to take a simpler approach and apply it to biological disease markers.
The researchers started with tiny spherical pouches called liposomes and filled them with enzymes that produce glucose. In the presence of a target molecule, the liposomes were designed to burst open and cause an increase of glucose in the test solution. The researchers tried it with thrombin, a protein that can indicate restricted blood flow or heart disease. A commercial glucose monitor accurately detected the levels of glucose, which corresponded to the amount of thrombin in samples. In addition, the researchers say their method could be used to detect other disease-associated proteins.
The authors acknowledge funding from the National Natural Science Foundation of China, the National Basic Research Program of China, the National Instrumentation Program of China and the National Foundation for Fostering Talents of Basic Sciences (China).
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