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Genetics and brain regions linked to sex differences in anxiety-related behavior in chimpanzees

Georgia State University


IMAGE: Robert Latzman is lead author of the study and assistant professor in the Department of Psychology at Georgia State University. view more

Credit: Georgia State University

ATLANTA--Genetics and specific brain regions are linked to sex differences in chimpanzees' scratching behavior, a common indicator of anxiety in humans and others primates, according to a research study led by Georgia State University that shows chimpanzees can be models of human mental illness.

The researchers investigated genetic and neuroanatomical links to individual variation in scratching, a behavioral indicator of negative emotional states, such as stress, anxiety and frustration. They studied genes associated with vasopressin, a neuropeptide that has been strongly implicated in the development and evolution of complex social behavior in mammals. In particular, they examined different forms of the promoter region of the vasopressin V1a receptor gene (AVPRIA), known as DupA and DupB. The findings are published in a special issue of the journal Psychophysiology devoted to reshaping clinical science.

The project demonstrates how studies with chimpanzees can contribute to the National Institute of Mental Health's recently introduced Research Domain Criteria (RDoC), which aims to explain the neurobiological basis of mental illness. This study targets the RDoC Negative Valence Systems domain, one of five broad categories intended to provide a framework for psychopathology research.

"In combination with findings from human studies, work with chimpanzees can provide enormous insights into core biobehavioral processes relevant to psychological illness and health," said Robert Latzman, lead author of the study and assistant professor in the Department of Psychology at Georgia State.

In humans and other primates, self-directed displacement behaviors often take the form of self-grooming actions, such as head scratching or beard stroking, which indicate anxiety related to uncertainty, social tension or impending danger.

Researchers assessed scratching behaviors in 76 chimpanzees housed in social groups at Yerkes National Primate Research Center. The sample included 45 chimpanzees with the DupB-/- genotype and 31 chimpanzees with the DupB+/- genotype. To elicit scratching in experimental conditions, the chimpanzees were shown a 30-minute video that included scenes and vocalizations of unfamiliar chimpanzees negotiating possession and sharing of watermelon. Scratching behavior was recorded in the subjects before and after watching the video, with a minimum of 12 hours in between. DNA samples were also taken, and each chimpanzee was genotyped for the AVPRIA Dup A/B region. In addition, chimpanzees completed magnetic resonance imaging (MRI) scans.

Analysis revealed that for males, DupB+/- individuals showed significantly higher rates of scratching than DupB-/- apes. In contrast for females, DupB+/- individuals scratched significantly less than DupB-/-. The study also found significant differences between DupB-/- and DupB+/- apes in 12 distinct brain regions, with the largest clusters within the frontal lobe.

"Some have speculated that vasopressin may exert stronger effects on male social behavior, and our findings seem to support this claim," Latzman said.

Significant sex differences were also found for rates of scratching and mean gray matter intensity values in certain areas of the brain. For males, increased scratching rates were associated with lower gray matter values. In contrast, increased scratching rates were associated with higher gray matter values in females.


Co-authors for the study include William Hopkins, professor in the Neuroscience Institute at Georgia State and researcher at the Yerkes National Primate Research Center, and Larry Young of the Yerkes National Primate Research Center and Emory University School of Medicine.

The study was funded by the National Institutes of Health and the National Center for Research Resources.

To read the study, visit

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