Public Release: 

Study shows hip fracture risk rises in the 10 years after total knee replacement

In a study presented at the World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases, Swedish researchers analyzed hip fracture risk before and after total knee replacement, based on data from the entire Swedish population

International Osteoporosis Foundation

Researchers from the Sahlgrenska Academy in Molndal, Sweden have published preliminary results of a fracture risk study, which was based on analysis of medical records from 1987 to 2002 covering the entire Swedish population born between 1902 and 1952.

They were able to show that individuals with total knee replacement (TKR) due to primary osteoarthritis had a low risk for hip and vertebral fracture in the decade before surgery. However, after total knee replacement, the risk for hip fracture increased by 4% and the risk for vertebral fracture increased by 19% percent compared to the population without TKR.

A total of 3221 patients had both total knee replacement and hip fracture. The hazard ratio (HR) for patients with knee OA to have sustained a hip fracture during the ten years preceding TKR was 0.58 (0.54-0.63) and during the ten year after the surgery 1.04 (1.00-1.09). The HR for patients with knee OA to have sustained a vertebral fracture during the ten years preceding TKR was 0.55 (0.47-0.65) and during the ten year after the surgery 1.19 (1.09-1.31). The lower risk of hip or vertebral fracture before and the increasing risk of hip or vertebral fracture after TKR remained after adjustment for age, gender, calendar year, and latitude. The HR for mortality the first year after TKR was 0.40 (0.37-0.44) and after 10 years after TKR 1.06 (1.00-1.11).

Lead author C. H. Vala, said, "Studies have shown that osteoarthritis is associated with higher bone mass, and, as well, there may be a decreased physical activity level due to pain. The increasing risk for hip and vertebral fracture in the 10 years after knee replacement may be explained by pain, increase of physical activity due to rehabilitation, and other biomechanical factors. With approximately 13,000 total knee replacements carried out in Sweden annually, further research on the increased fracture risk in this population group is needed."

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Reference:

OC12 Risk for hip fracture ten years before and after total knee replacement surgery in the entire Swedish population Abstract book: WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, 14 -17 April 2016, Malaga, Spain Osteoporosis International, Volume 27/ Suppl 1/ 2016

About World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO 2016):

Held jointly by IOF and ESCEO, the Congress is taking place in Malaga, Spain from April 14-17,2016. It is the world's largest annual forum for the presentation of clinical research and new advances in the prevention and management of bone, muscle and joint disorders, including sarcopenia and frailty. The next Congress will be held in Florence, Italy from March 23-26, 2017. For complete information visit http://www.wco-iof-esceo.org #OsteoCongress

About IOF:

The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers, leading companies, as well as more than 234 patient, medical and research societies in 99 locations, work together to make bone, joint and muscle health a worldwide heath care priority. http://www.iofbonehealth.org / http://www.facebook.com/iofbonehealth / https://twitter.com/iofbonehealth

About ESCEO:

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) is a non-profit organization, dedicated to a close interaction between clinical scientists dealing with rheumatic disorders, pharmaceutical industry developing new compounds in this field, regulators responsible for the registration of such drugs and health policy makers, to integrate the management of osteoporosis and osteoarthritis within the comprehensive perspective of health resources utilization. The objective of ESCEO is to provide practitioners with the latest clinical and economic information, allowing them to organize their daily practice, in an evidence-based medicine perspective, with a cost-conscious perception. http://www.esceo.org

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