Public Release: 

UK study supports cardiovascular safety of calcium and vitamin D supplementation

Study presented at WCO-IOF-ESCEO 2016 finds no link between calcium supplementation, with or without vitamin D, and hospital admissions or mortality due to cardiovascular events

International Osteoporosis Foundation

UK researchers have presented a new study that supports the cardiovascular safety of calcium and vitamin D supplementation. The study was based on analysis of the UK Biobank, a very large study comprising 502,664 men and women aged 40-69 years.

Of the total UK Biobank participants, 34,890 individuals (6.94%) reported taking calcium supplements, 20,004 taking vitamin D supplements, and 10,406 taking both (2.1%). The researchers found no associations between the use of calcium supplements and hospital admissions related to ischaemic heart disease (e.g. heart attacks), any cardiovascular event, or death following admission for either admission category. Results were similar for vitamin D and combination supplementation.

Furthemore, regardless of whether participants had a history of cardiovascular disease or not at baseline, calcium supplementation (with or without vitamin D) did not increase the risk of future cardiac events, findings which remained robust after other factors such as age, fatness, medication use and blood pressure were considered.

Presenting author Prof. Nicholas C. Harvey of the MRC Lifecourse Epidemiology Unit, University of Southampton, noted, "Calcium supplementation is widely used, including as an adjunct to therapy for osteoporosis. Previous studies have provided inconsistent findings with regard to associations between calcium supplements and cardiovascular events. Our results, using the largest single study to date, provide reassurance that such supplementation appears safe."

Professor Cyrus Cooper, Director of the MRC Lifecourse Epidemiology Unit, University of Southampton, added, "This study illustrates the importance for the University of Southampton and MRC Lifecourse Epidemiology Unit in leading large, multicentre analyses on this internationally leading UK Biobank dataset. The findings will be built upon in further analyses that capitalise on the genetic and intensive musculoskeletal phenotyping components of the study in which we continue to play an important role."

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Reference:

Calcium and vitamin D supplementation are not associated with increased risk of ischaemic cardiac events: results from UK Biobank.

N.C Harvey, S. D'Angelo, J. Paccou, M. Edwards, S.E. Petersen, C. Cooper

Abstract book: WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, 14 -17 April 2016, Malaga, Spain Osteoporosis International, Volume 27/ Suppl 1/ 2016

About World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO 2016):

Held jointly by IOF and ESCEO, the Congress is taking place in Malaga, Spain from April 14-17, 2016. It is the world's largest annual forum for the presentation of clinical research and new advances in the prevention and management of bone, muscle and joint disorders, including sarcopenia and frailty. The next Congress will be held in Florence, Italy from March 23-26, 2017. For complete information visit http://www.wco-iof-esceo.org #OsteoCongress

About IOF:

The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers, leading companies, as well as more than 234 patient, medical and research societies in 99 locations, work together to make bone, joint and muscle health a worldwide heath care priority. http://www.iofbonehealth.org / http://www.facebook.com/iofbonehealth/https://twitter.com/iofbonehealth

About ESCEO:

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) is a non-profit organization, dedicated to a close interaction between clinical scientists dealing with rheumatic disorders, pharmaceutical industry developing new compounds in this field, regulators responsible for the registration of such drugs and health policy makers, to integrate the management of osteoporosis and osteoarthritis within the comprehensive perspective of health resources utilization. The objective of ESCEO is to provide practitioners with the latest clinical and economic information, allowing them to organize their daily practice, in an evidence-based medicine perspective, with a cost-conscious perception. http://www.esceo.org

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