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Obese or anorexic individuals react differently to taste, CU Anschutz study says

Flavors either too intense or hard to distinguish

University of Colorado Anschutz Medical Campus

AURORA, Colo. (May 16, 2016) - Researchers at the University of Colorado Anschutz Medical Campus have discovered that women suffering from anorexia nervosa and those who are obese respond differently to taste, a finding that could lead to new treatments for the eating disorders.

"Taste is an important driver of food intake and invariably associated with distinct neuronal patters in the insula, the brain's primary taste cortex," said the study's lead author Guido Frank, MD, a psychiatrist and associate professor at the CU School of Medicine.

The study was recently published online in the International Journal of Eating Disorders.

Frank and his team set out to find if abnormal eating patterns were associated with changes in the insula's ability to classify taste stimuli.

Some 106 women of similar age underwent brain imaging while tasting sugar water or a tasteless water solution. Researchers studied how well the insula could differentiate between the flavors.

Individuals with anorexia nervosa or those who were obese, had difficulty distinguishing between ordinary water and sugar water, compared to control subjects and those who had recovered from anorexia nervosa.

"If you can't differentiate between tastes, that could impact how much you eat," Frank said. "That could also activate or not activate brain reward circuits."

These changes, he said, could occur on a variety of levels. For example, leptin and other hormones are altered in obesity and eating disorders, affecting how the brain responds to food. At the same time, the reduced ability of the insula to classify taste could be due to structural changes within this brain region or alternatively could result in altered taste signal processing in different pathways to the insula.

Research indicates that these problems diminish once a person reaches a healthy weight.

While more research is needed, Frank said one possible treatment could be to alter the taste of food.

"Perhaps adjusting flavor intensity by reducing it for those with anorexia and enhancing it for those who are obese," he said. "It's something we need to examine more closely."

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The University of Colorado Anschutz Medical Campus

The University of Colorado Anschutz Medical Campus is the only comprehensive academic health sciences center in Colorado, the largest academic health center in the Rocky Mountain region and one of the newest education, research and patient care facilities in the world. Home to 21,000 employees, more than 4,000 degree-seeking students and two nationally recognized hospitals that handle 1.7 million patient visits each year, CU Anschutz trains the health sciences workforce of the future and fuels the economy. CU Anschutz features schools of medicine, pharmacy, dental medicine and public health, a college of nursing and a graduate school. All interconnected, these organizations collaboratively improve the quality of patient care they deliver, research they conduct, and health professionals they train.

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