Most diseases are multifactorial, such as diabetes, cardiovascular diseases and cancer. They involve complex interactions within a patient's body that are additionally influenced by external factors. Mathematical models and computer simulations have been successfully developed to achieve a better understanding of complex biological interactions. The application of such a systems approach in a clinical setting is called Systems Medicine and represents a powerful method to improve:
- poly-pharmacology treatment in the elderly population
- Integration of personalized genomics, proteomics and clinical phenotyping
- Identification of biomarkers for early diagnosis, prognosis and personalized therapies
- Molecular re-classification of diseases thereby optimising P4-medicine (predictive, personalized, preventive, participatory) and drug development
The aim of EASyM is the implementation of Systems Medicine in clinical research and healthcare in Europe. EASyM has been initiated by the European FP7-funded Coordinating Action Systems Medicine (CASyM, http://www.
At the 1st Conference of EASyM, cases of successful usage of Systems Medicine will be presented, as well as talks and tutorials about big data, omics, bioinformatics, doctor and patient involvement together with compliance with privacy regulations. Key note speakers include Leroy Hood, MD, PhD, Co-founder and Chairman of the P4 (predictive, personalised, preventive, participatory) Medicine Institute, Seattle, USA and Dame Janet Thornton, PhD, former director of EMBL-EBI. The conference is aimed at basic and clinical researchers in academia and industry who want to apply Systems Medicine approaches to address unmet clinical needs.
Dr. Charles Auffray, Chairman of EASyM, says: « The European Association of Systems Medicine (EASyM) is now set to transform into a concrete action plan the road map of the Coordinating Action CASyM to implement Systems Medicine in Europe. This will be achieved in pilot projects tackling unmet medical needs through systems approaches of biological processes across organs and pathologies, leveraging European biomedical and ICT infrastructures. EASyM is committed to ensure that Europe speaks with a unified voice on the international scene to foster the development of the proactive and personalized medicine of the future ».
European Association of Systems Medicine e.V.
c/o JRC for Computational Biomedicine
Prof. Dr. Schuppert
RWTH Aachen University