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CVIA special issue on Intervention

Cardiovascular Innovations and Applications


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Credit: CVIA

Special Issue on Intervention published: Cardiovascular Innovations and Applications

Cardiovascular Innovations and Applications (CVIA) has just published its third issue which is available online now.

This new issue has a special focus on Intervention and was guest edited by R. David Anderson of the Division of Cardiovascular Medicine at the University of Florida Medical School. This CVIA special issue brings together contributions from leading cardiologists from Europe, the United States and China.

CVIA is the official journal of the Great Wall International Congress of Cardiology (GW-ICC) and its first issue was published in October 2015 to coincide with the GW-ICC meeting in Beijing, China.

Featured papers in this issue include:

Reports of a possible causal link between brain, head, and neck tumors and radiation exposure during coronary interventional procedures: a sobering look at the data by Ryan Reeves and Ehtisham Mahmud (DOI 10.15212/CVIA.2016.0014.

This paper explores the hazard posed by radiation exposure for both patients and physicians during fluoroscopically-guided procedures. Drs. Ryan and Mahmud write '' Invasive cardiologists are exposed to high levels of scatter radiation and both increasing procedural complexity and higher operator volumes contribute to exposure above recommended thresholds. Standard shielding does not offer sufficient protection to the head and neck region and the potential for negative biological, subclinical, and clinical effects exists. Large population studies suggest that cranial exposure to low dose radiation increases the risks of tumor development. In addition, modest doses of therapeutic cranial radiation have been linked with the development of brain cancer. Although a causal association between scatter radiation in the cath lab and brain cancer does not currently exist, given the known detrimental effects of radiation exposure to the head and neck region, support a focus on potential methods of protection for both the patient and the operator.''

Renal Denervation: Past, Present, and Future by Negiin Pourafshar, Ashkan Karimi, R David Anderson, Seyed Hossein Alaei-Andabili and David E Kandzari (DOI 10.15212/CVIA.2016.0016)

Over the past decade, percutaneous renal denervation has been vigorously investigated as a treatment for resistant hypertension. The SYMPLICITY radiofrequency catheter system (Medtronic CardioVascular Inc., Santa Rosa, CA, USA) is the most tested device in clinical trials. After the positive results of small phase I and II clinical trials, SYMPLICITY HTN-3 (a phase III, multi-center, blinded, sham-controlled randomized clinical trial) was completed in 2014, but did not show significant blood pressure lowering effect with renal denervation (RDN) compared to medical therapy and caused the investigators and industry to revisit both the basic science elements of RDN as well as the design of related clinical trials. This review summarizes the SYMPLICITY trials, analyzes the SYMPLICITY HTN-3 data, and provides insights gained from this trial in the design of the most recent clinical trial, the SPYRAL HTN Global clinical trial. Other than hypertension, the role of RDN in the management of other disease processes such as systolic and diastolic heart failure, metabolic syndrome, arrhythmia, and obstructive sleep apnea with the common pathophysiologic pathway of sympathetic overactivity is also discussed. The authors conclude that ''In the past decade there has been a significant increase in renal denervation (RDN) devices with proprietary design using various energy sources, and as investigators strive to discover the role of RDN in the management of hypertension, there is a future need for direct comparative study between these technologies to identify the safest and most effective device.''



NSTEMI or STEMI: A Myocardial Infarction is an Infarction regardless of the ECG Changes at Presentation by C. Richard Conti (DOI 10.15212/CVIA.2016.0006)

In this Commentary, Dr Conti considers ST-segment elevation myocardial infarction (STEMI) and non-ST segment elevation myocardial infarction (NSTEMI). He concludes '' Some have the impression that NSTEMI is benign compared to STEMI and thus need not be considered for urgent revascularization. The message I am getting from the literature is that there is insufficient evidence to accept or reject the emergent use of coronary angiography and subsequent PCI/Stent in the NSTEMI patient. I guess my message is that if we do no harm, (with urgent coronary angiography) why not find out what is going on in the coronary circulation? We might be surprised in patients in whom the diagnosis of vessel occlusion was missed.''

Other papers in this issue include:

Fractional Flow Reserve-guided Percutaneous Coronary Intervention: Standing the Test of Timeby Frederik M. Zimmermann, Lokien X. van Nunen (DOI 10.15212/CVIA.2016.0011)

What is the Optimal Duration of Dual Antiplatelet Therapy After Stenting? by Udaya S. Tantry, Eliano P. Navarese and Paul A. Gurbel (DOI 10.15212/CVIA.2016.0022)

Current Considerations of Thrombectomy for Acute Myocardial Infarction by Ahmed N. Mahmoud, Islam Y. Elgendy and Anthony A. Bavry (DOI 10.15212/CVIA.2016.0021)

Will transcatheter aortic valve replacement (TAVR) be the primary therapy for aortic stenosis? by Jose F. Condado and Peter C. Block (DOI 10.15212/CVIA.2016.0012)

The future of transcatheter therapy for mitral valve disease by Ted Feldman and Mayra Guerrero (DOI 10.15212/CVIA.2016.0017)

The Transradial Approach for Cardiac Catheterization and Percutaneous Coronary Intervention: A Review by Dhaval Pau, Nileshkumar J Patel, Nish Patel and Mauricio G. Cohen (DOI 10.15212/CVIA.2016.0013)

Carotid Artery Stenting: 2016 and Beyond by Christopher Bajzer (DOI 10.15212/CVIA.2016.0015)

Coronary Artery Chronic Total Occlusion by Calvin Choi, Nayan Agarwal, Ki Park and R. David Anderson (DOI 10.15212/CVIA.2016.0023)

Cardiovascular Abnormalities Among Patients with Spontaneous Subarachnoid Hemorrhage. A Single Center Experience by Akram Y. Elgendy, Ahmed Mahmoud, Islam Y. Elgendy, Hend Mansoor and C. Richard Conti (DOI 10.15212/CVIA.2016.0024)

Identification and Management of Iatrogenic Aortocoronary Dissection by Shao-Ping Nie and Xiao Wang (DOI 10.15212/CVIA.2016.0018)


Transient Pulmonary Atelectasis after Ketamine Sedation during Cardiac Catheterization in Spontaneously Breathing Children with Congenital Heart Disease by Yan Chaowu, Xu Zhiongying, Zhang Gejun, Zheng Hong, Jin Jinglin, Li Shiguo, Lv Jianhua, Hu Haibo, Song Huijun, Zhao Shihua (DOI 10.15212/CVIA.2016.0019)


Should Patients with Acute Myocardial Infarction Have Complete Revascularization at the Time of PCI of the Culprit Vessel? ) by C. Richard Conti (DOI 10.15212/CVIA.2016.0008)


Biodegradable Stents by C. Richard Conti (DOI 10.15212/CVIA.2016.0010)

CVIA is an open access journal with no author submission or article processing fees during its launch phase. C. Richard Conti acts as Editor-in-chief and all articles are subject to full and transparent peer review. CVIA is available on the IngentaConnect platform and at Submissions may be made using ScholarOne Manuscripts (

There are no author submission or article processing fees.

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