ST. LOUIS - In research featured in the August edition of Obesity, Saint Louis University investigator Andrew Butler, Ph.D., and his team report that levels of the peptide hormone adropin vary based on carbohydrate consumption and appear to be linked to lipid metabolism.
Butler, who is professor of pharmacology and physiology at SLU, discovered adropin several years ago. Data from previous studies in mice suggest it plays a role in metabolic diseases of obesity; however, the function of the hormone in humans remains unclear.
"This study shows that the levels of adropin in blood correlate with carbohydrate intake. Higher habitual intake of carbs is associated with lower levels of adropin. Conversely, a proportionately higher intake of fat may be associated with higher levels of adropin," Butler said.
"It may be that habitual consumption of carbohydrate-rich diets suppress circulating levels of adropin."
Further, people with low levels of the hormone had higher fat content in the blood. Levels of LDL (bad) cholesterol and triglycerides were observed in people with low adropin. Low levels of adropin may therefore be associated with higher risk of heart disease.
Butler anticipates that further studies may confirm that adropin could be a useful biomarker of the body's long term metabolic processes, such as fuel selection.
"This study is just a snapshot and it says that there is a link with diet," Butler said. "It further implies that adropin may have a role in maintaining healthy metabolic control."
Other researchers on the paper include Joseph R. Stevens, Monica L. Kearney, Marie-Pierre St-Onge, Kimber L. Stanhope, Peter J. Havel, Jill A. Kanaley, John P. Thyfault and Edward P. Weiss.
The study was funded by Novo Nordisk's Diabetes Innovation Award Program, the Lottie Caroline Hardy Charitable Trust, the National Institutes of Health, University of California and University of Missouri Research Council.
Read more about Butler's work studying adropin: http://www.
Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in five key areas: cancer, liver disease, heart/lung disease, aging and brain disease, and infectious diseases.