Public Release: 

Einstein-Montefiore and CUNY research team receives $9.4 million to lead study of HIV/AIDS care in Central Africa

Research collaboration seeks to improve clinical outcomes for patients with HIV

Albert Einstein College of Medicine

August 15, 2016--(BRONX, NY)--Albert Einstein College of Medicine and Montefiore, in collaboration with the City University of New York (CUNY), have received a $9.4 million grant from the National Institutes of Health (NIH) to lead research in Central Africa to improve clinical care and health outcomes for patients with HIV. The ongoing, five-country observational study, called Central Africa International Epidemiologic Databases to Evaluate AIDS (CA-IeDEA), involves more than 50,000 HIV-positive children and adults taking anti-retroviral therapy (ART).

"During our first five years leading CA-IeDEA, we built the research capacity and technical infrastructure for tackling this enormous project," said dual principal investigator Kathy Anastos, M.D., professor of medicine, of epidemiology & population health, and of obstetrics & gynecology and women's health at Einstein and attending physician, general internal medicine at Montefiore. "Over the next five years, we will use our high-quality data to address scientific clinical and healthcare delivery questions that will inform care in Central Africa and beyond." Dr. Anastos is also co-director of the Global Health Center at Einstein.

CA-IeDEA partners with the governments of five nations--Burundi, Cameroon, Rwanda, and the Democratic Republic of Congo--and will extend the collaboration to the Republic of Congo. Researchers and health workers based in each country regularly collect de-identified data from electronic medical records, which are integrated into an external database for analysis. Over the next five years, the team will increase the number of clinical sites involved in the study from 15 to 20 as CA-IeDEA expands into more rural areas.

CA-IeDEA is a member of the International Epidemiologic Databases to Evaluate AIDS (IeDEA), a global research consortium with seven regional members. The members collaborate with each other and external groups, including the World Health Organization and PEPFAR, to address the evolving questions in HIV/AIDS.

CA-IeDEA researchers will use the data for their own research projects. Dr. Anastos, the chair of IeDEA's Clinical Outcomes working group, will lead clinical investigations, such as how do blood test results change over the course of treatment or vary by age and gender.

By following how, when and under what circumstances patients enter and leave care, investigators can identify challenges to providing high-quality treatment and services. This field, also known as implementation science, seeks to improve health outcomes by considering changes in the administration of care. Denis Nash, Ph.D., dual principal investigator of CA-IeDEA, will pursue this area of research. Dr. Nash is professor at the CUNY School of Public Health and executive director of CUNY's Institute for Implementation Science in Population Health. He is also adjunct clinical professor of epidemiology & population health at Einstein.

"The IeDEA project is helping us learn more about the models and approaches to HIV care delivery at scale that result in optimal clinical outcomes, such as long-term retention in care and survival" said Dr. Nash. "Through IeDEA, we are also learning about the ability of HIV clinical sites to diagnose and manage other chronic conditions, such as hypertension, diabetes, and mental illness. This is very cutting edge work, with relevance to health systems in Central Africa and beyond."


The grant is titled "Central Africa International Epidemiologic Database to Evaluate Aids" (U01AI096299).

About Albert Einstein College of Medicine

Albert Einstein College of Medicine is one of the nation's premier centers for research, medical education and clinical investigation. During the 2015-2016 academic year, Einstein is home to 731 M.D. students, 193 Ph.D. students, 106 students in the combined M.D./Ph.D. program, and 278 postdoctoral research fellows. The College of Medicine has more than 1,900 full-time faculty members located on the main campus and at its clinical affiliates. In 2015, Einstein received $148 million in awards from the National Institutes of Health (NIH). This includes the funding of major research centers at Einstein in aging, intellectual development disorders, diabetes, cancer, clinical and translational research, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore Medical Center, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. Through its extensive affiliation network involving Montefiore, Jacobi Medical Center--Einstein's founding hospital, and three other hospital systems in the Bronx, Brooklyn and on Long Island, Einstein runs one of the largest residency and fellowship training programs in the medical and dental professions in the United States. For more information, please visit, read our blog, follow us on Twitter, like us on Facebook, and view us on YouTube.

About Montefiore Health System

Montefiore Health System is a premier academic health system and the University Hospital for Albert Einstein College of Medicine. Combining nationally-recognized clinical excellence with a population health perspective that focuses on the comprehensive needs of the communities it serves, Montefiore delivers coordinated, compassionate, science-driven care where, when and how patients need it most. Montefiore consists of six hospitals and an extended care facility with a total of 2,080 beds, a School of Nursing, and state-of-the-art primary and specialty care provided through a network of more than 150 locations across the region, including the largest school health program in the nation and a home health program. The Children's Hospital at Montefiore is consistently named in U.S. News' "America's Best Children's Hospitals." Montefiore's partnership with Einstein advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. The health system derives its inspiration for excellence from its patients and community, and continues to be on the frontlines of developing innovative approaches to care. For more information please visit Follow us on Twitter; like us on Facebook; view us on YouTube.

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