New research published online in The FASEB Journal shows that in rats, a substance called a ketone ester significantly increase exercise endurance, cognitive function and energy levels in the heart at high workloads. Ketone esters are small organic chemicals that provide energy for the heart, brain and skeletal muscle in a highly efficient way, but are typically produced by the body only during periods of food scarcity and are not naturally present in typical modern diets.
"The dramatic improvements in exercise performance and cognitive function will no doubt interest athletes and professional sports teams worldwide. Our hope, however, is that ketone ester supplementation will also hold benefits for people who are suffering from debilitating metabolic and neurological diseases by improving energy availability," said Andrew J. Murray, Ph.D., a researcher involved in the work from the Department of Physiology, Development and Neuroscience at the University of Cambridge, in Cambridge, England. "Further research into the potential benefits of ketone ester for human health is vital, and only just beginning."
To make this discovery, Murray and colleagues fed three different diets to rats for five days. A third of the calories in the diets were from a novel ketone ester, or fat, or carbohydrate. To test endurance, the rats ran on a treadmill. To test memory, the rats had to complete a maze. The researchers found that the ketone ester-fed rats ran farther and completed the maze faster and more accurately than rats on the carb or fat diets. Additional work described in the study shows that the ketone ester diet also improved energy production in the heart itself.
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"These endogenous compounds have long been known in the metabolism field but here one is being used exogeneously," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "This may be a new horizon on the energy balance sheet in certain nutrional or physiological situations"
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FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
Details: Andrew J. Murray, Nicholas S. Knight, Mark A. Cole, Lowri E. Cochlin, Emma Carter, Kirill Tchabanenko, Tica Pichulik, Melanie K. Gulston, Helen J. Atherton, Marie A. Schroeder, Robert M. J. Deacon, Yoshihiro Kashiwaya, M. Todd King, Robert Pawlosky, J. Nicholas P. Rawlins, Damian J. Tyler, Julian L. Griffin, Jeremy Robertson, Richard L. Veech, and Kieran Clarke. Novel ketone diet enhances physical and cognitive performance. FASEB J. doi:10.1096/fj.201600773R ; http://www.