Oral and genital herpes are caused by the herpes simplex virus type 1 (HSV-1) and the herpes simplex virus type 2 (HSV-2), which both cause lifelong infection. HSV-2 infection is associated with increased risk for HIV infection. HSV2-infected women pose a risk of transmitting this dangerous infection to newborn babies; therefore, avoiding herpes infection during pregnancy is very important. In this issue of JCI Insight, researchers from the Albert Einstein College of Medicine report a promising vaccine strategy for immunizing against both HSV-1 and HSV-2 infections. Led by Betsy Herold and William Jacobs Jr., the researchers expanded upon previous work from their group indicating that a vaccine made from an engineered HSV-2 virus that lacks expression of glycoprotein D could protect against infection with a single strain of HSV-2 in mice. The current report shows that vaccination protects mice from multiple clinical isolates of HSV-1 and HSV-2 infection. Mice rapidly cleared virus after infection and did not develop long-term latent infections. These studies provide exciting preclinical support for a new vaccine strategy to prevent infection by herpes viruses.
TITLE: HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates
Albert Einstein College of Medicine
William R. Jacobs Jr.,
Howard Hughes Medical Institute Investigator,
Albert Einstein College of Medicine.
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