Public Release: 

Largest review into twin pregnancies reveals ideal delivery time to prevent stillbirths

Queen Mary University of London

Scientists at Queen Mary University of London (QMUL) have analysed the twin pregnancies of more than 30,000 women to identify the ideal delivery period in an attempt to reduce rates of stillbirth.

In the largest review of its kind the researchers recommend that in the case of pregnancies without complications, women with dichorionic twins (twins with separate placenta) should be offered delivery after 37 weeks. They also recommend that women with monochorionic twins (twins that share the same placenta) should not be offered delivery before 36 weeks.

The study was published in the British Medical Journal.

Twin pregnancies are high risk with a thirteen-fold increase in rates of stillbirth in monochorionic twins, and a five-fold increase in dichorionic twins, compared with singleton pregnancies.

Uncomplicated twin pregnancies are often delivered early in an attempt to prevent late stillbirth but delivery before term can lead to neonatal complications associated with prematurity.

Professor Shakila Thangaratinam, of the Women's Health Research Unit at QMUL's Blizard Institute, said: "Until now, we did not have clear recommendations on the best time to offer delivery to mothers with twin pregnancies. We know that women with twin pregnancies have a higher risk of stillbirth compared to women with singleton pregnancies, and this risk gets higher the later they are in pregnancy. However, earlier delivery can put the babies at risk of problems associated with being born prematurely including neonatal death."

Since 2005, the number of patient safety incidents involving multiple pregnancies, including unexpected stillbirth and neonatal death, has risen by 419 per cent in the UK, and peaked in 2013-14, resulting in payouts of over £90m.

Professor Thangaratinam added: "There is a global drive to prevent stillbirths and we know that twin pregnancies are a major risk factor for stillbirths in high income countries. We hope that this research will help to complement national and international efforts to reduce the rates of stillbirth and unexpected neonatal complications in babies from women with twin pregnancies and will be useful to national guideline and hospital policy makers."

The research was carried out in collaboration with the Global Obstetrics Network (GONET).

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More information:

* Research paper: 'Prospective risk of stillbirth and neonatal complications in twin pregnancies: A systematic review and meta-analysis'. Fiona Cheong-See, Ewoud Schuit, David Arroyo-Manzano, Asma Khalil, Jon Barrett, KS Joseph, Elizabeth Asztalos, Karien Hack, LIesbeth Lewi, Arianne Lim, Sophie Liem, Jane E Norman, John Morrison, C Andrew Combs, Thomas J Garite, Kimberly Maurel, Vicente Serra, Alfredo Perales, Line Rode, Katharina Worda, Anwar Nassar, Mona Aboulghar, Dwight Rouse, Elizabeth Thom, Fionnuala Breathnach, Soichiro Nakayama, Francesca Maria Russo, Julian Robinson, Jodie M Dodd, Roger B Newman, Sohinee Bhattacharya, Selphee Tang, Ben Willem J Mol, Javier Zamora, Basky Thilaganathan, Shakila Thangaratinam. British Medical Journal.

Notes to editors:

Queen Mary University of London (QMUL) is one of the UK's leading universities, and one of the largest institutions in the University of London, with 20,260 students from more than 150 countries.

A member of the Russell Group, we work across the humanities and social sciences, medicine and dentistry, and science and engineering, with inspirational teaching directly informed by our research - in the most recent national assessment of the quality of research, we were placed ninth in the UK (REF 2014).

We also offer something no other university can: a stunning self-contained residential campus in London's East End. As well as our home at Mile End, we have campuses at Whitechapel, Charterhouse Square and West Smithfield dedicated to the study of medicine, and a base for legal studies at Lincoln's Inn Fields.

We have a rich history in London with roots in Europe's first public hospital, St Barts; England's first medical school, The London; one of the first colleges to provide higher education to women, Westfield College; and the Victorian philanthropic project, the People's Palace at Mile End.

Today, as well as retaining these close connections to our local community, we are known for our international activities, and have research and teaching partnerships with leading universities around the world. This includes two very successful and long-standing joint partnerships with the Beijing University of Posts and Telecommunications, and Nanchang University.

QMUL has an annual turnover of £350m, a research income worth £100m, and generates employment and output worth £700m to the UK economy each year.

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