Public Release: 

New breakthrough for IBS patients

Fecal bacterial profiles could help to find IBS patients most likely to respond to a low-FODMAP diet

Spink Health

(Vienna, October 18, 2016) A low-FODMAP diet is now an established treatment for people with irritable bowel syndrome (IBS), but the diet is controversial and challenging to follow, and not all IBS sufferers have a positive response to the intervention. Today, scientists at UEG Week have announced that bacterial profiles in the faeces differ between people who do and do not respond to a low-FODMAP diet, allowing doctors to predict who might benefit most from using the diet.

Presenting their findings for the first time at the opening session of UEG Week 2016, Dr Sean Bennet from the University of Gothenburg in Sweden, told delegates that, in the right people, a low-FODMAP diet can be highly effective, but identifying those individuals is currently impossible. "A low-FODMAP diet has been shown in a recent clinical trial to significantly reduce the symptoms of IBS in around half of the people who tried it," he said. "Unfortunately, this is a very demanding diet that requires the exclusion of entire food groups, so we have been looking at ways to predict who will gain the greatest benefit from trying it."

What is the low-FODMAP diet?

Dietary interventions are considered to be first-line treatments for patients with IBS. A 'traditional' IBS diet focusses on optimizing eating patterns and reducing the intake of specific foodstuffs that are known to worsen symptoms in some people. The low-FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols) diet requires restriction of certain carbohydrates, including foods such as wheat, barley, onion and legumes, foods rich in free fructose (including many fruits), and artificially sweetened products.

"We know that the low-FODMAP diet is effective in many IBS patients, but we also know that the diet can alter the composition of the gut bacteria," said Dr Bennet. "We wanted to compare the effects of the 'traditional' and low-FODMAP diets on the gut bacteria and see whether the bacterial profiles can be used to predict patient response to each treatment."

Predicting low-FODMAP diet responders: latest research

The study presented today by Dr Bennet and colleagues involved an analysis of data from 61 patients with moderately severe or severe IBS symptoms who took part in a previous clinical trial. In that trial, patients followed a 'traditional' or low-FODMAP diet for 4 weeks, with faecal samples collected before and after the dietary interventions. Bacterial profiling of the samples found differences in the impact of each diet on the gut bacteria composition and also revealed that the faecal bacterial profiles differed between patients who responded to the low-FODMAP diet and those who did not.

"Patients who did not respond to the low-FODMAP diet were found to have more abnormalities in their gut bacterial profiles before they started the diet than those who responded to the diet," said Dr Bennet. "This raises the possibility that faecal bacterial profiling could be undertaken before dietary interventions are considered."

"Being able to predict if a patient is unlikely to respond to a low-FODMAP diet means that other therapies could be discussed earlier, and these patients could be spared a demanding diet that might have no effect on, or even worsen, their symptoms."

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References

1. Böhn L, Störsrud S, Liljebo T et al. Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. Gastroenterology 2015;149(6):1399¬-1407.

2. Halmos EP, Power VA, Shepherd SI et al. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology 2014;146(1):67-75.

3. Halmos EP, Christophersen CT, Bird AR et al. Diets that differ in their FODMAP content alter the colonic luminal microenvironment. Gut 2015;64(1):93-100.

4. Bennet SMP, Böhn L, Störsrud S et al. Multivariate modelling of gut microbial profiles predicts responsiveness to a diet low in FODMAPs. Oral presentation at UEG Week 2016, 15-19 October, Vienna, Austria. Abstract 3474.

Notes to Editors

For further information, or to arrange an interview with Dr Sean Bennet, please contact Luke Paskins on +44 (0)1444 811099 or media@ueg.eu

About Dr Sean Bennet

Dr Bennet is from the Department of Internal Medicine at the University of Gothenburg, Sweden. His study on gut microbial profiles and low-FODMAP diets has been selected as one of the top five abstracts submitted to UEG Week Vienna 2016: https://www.ueg.eu/awards-grants/ueg-week-awards/top-abstract-prize/

About Professor Hans Törnblom

Professor Törnblom is a member of the UEG Public Affairs Committee and is an Associate Professor at the Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.

About UEG Week

UEG Week is the largest and most prestigious gastroenterology meeting in Europe and has developed into a global congress. It attracts over 14,000 participants each year, from more than 120 countries, and numbers are steadily rising. UEG Week provides a forum for basic and clinical scientists from across the globe to present their latest research in digestive and liver diseases, and also features a two-day postgraduate course that brings together top lecturers in their fields for a weekend of interactive learning.

About UEG

UEG, or United European Gastroenterology, is a professional non-profit organisation combining all the leading European societies concerned with digestive diseases. Together, its member societies represent over 22,000 specialists, working across medicine, surgery, paediatrics, gastrointestinal oncology and endoscopy. This makes UEG the most comprehensive organisation of its kind in the world, and a unique platform for collaboration and the exchange of knowledge.

To advance standards of gastroenterological care and knowledge across Europe and the world, UEG offers numerous activities and initiatives, including:

  • UEG Week, the biggest congress of its kind in Europe, and one of the two largest in the world.
  • UEG Education, the universal source of knowledge in gastroenterology, providing online and classroom courses, a huge online library and delivering the latest GI news, fostering debate and discussion
  • Training Support, funding for innovative training and educational programmes, as well as international scientific and professional co-operations
  • UEG Journal, published bi-monthly, covering translational and clinical studies from all areas of gastroenterology
  • EU Affairs, promoting research, prevention, early diagnosis and treatment of digestive diseases, and helping develop an effective health policy for Europe

Find out more about UEG's work by visiting http://www.ueg.eu or contact: Luke Paskins on +44 (0)1444 811099 or media@ueg.eu

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