Psychotropic drug use is rather common among persons aged 90 years of more diagnosed with Alzheimer's disease compared with those who were diagnosed at younger age, concludes study conducted at University of Eastern Finland. Persons aged 90 years or more used antipsychotics 5 times and antidepressants 2.5 times more often than those without the disease in the same age group. The results were published in the Age and Ageing journal.
56% of persons aged 90 years or more with Alzheimer's disease use psychotropic drugs whereas the same figure was 48% among younger persons with Alzheimer's disease and 38% among those aged 90 years or more but without Alzheimer's disease. Psychotropic drugs include antipsychotics, antidepressants and benzodiazepines and related drugs which are used for anxiety and insomnia in short-term treatment. On the contrary, persons aged 90 years or more with Alzheimer's disease used less frequently antidementia drugs (63%) when compared with younger persons with the same disease (72%).
Psychotropic drugs are related to significant risk of adverse effects among older users and for this reason, very frequent use of these drugs among the oldest persons is concerning. The need and safety of drug use should be regularly assessed.
Drug use was studied within MEDALZ study cohort within six months after the diagnoses of Alzheimer's disease in Finland. Data for 67,215 persons with Alzheimer's disease diagnosed during 2005-2011 and comparison persons with same age, gender and region of residence without the disease were derived from Finnish nationwide registers.
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Heidi Taipale, Postdoctoral Researcher, School of Pharmacy, University of Eastern Finland, email@example.com
Sirpa Hartikainen, Professor, School of Pharmacy, University of Eastern Finland, firstname.lastname@example.org
Drug use in persons with and without Alzheimer's disease aged 90 years or more.
Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Anna-Maija Tolppanen, Jari Tiihonen, Sirpa Hartikainen. Age and Ageing, published online September 9, 2016.