Researchers have developed a new mouse model that could be used in Zika research to better understand the virus and find new treatments, according to a study published in PLOS Pathogens.
A person infected with Zika virus usually has no symptoms or only has mild ones. However, in recent outbreaks, the virus has been linked to increased rates of neurological disorders and birth defects. There is an urgent need for better animal models for laboratory research to study the Zika virus and potential treatments.
Previous studies have shown that young mice with specific immune system defects are susceptible to Zika infection. However, studying Zika in mice with compromised immune systems could skew results. Now, researchers at the U.S. Food and Drug Administration's Center for Drug Evaluation and Research demonstrate that mice with functioning immune systems can be successfully infected with Zika.
"This new mouse model developed by the FDA could be used to explore Zika virus' pathology and potentially help to develop treatments or vaccines," says Mohanraj Manangeeswaran, senior staff fellow in the FDA's Office of Pharmaceutical Quality. "Because the mice used in this model have immune systems that allow them to survive initial infection, they could be particularly helpful for studying the long-term effects of Zika virus infection."
The new mouse model employs a mouse strain called C57BL/6, which is commonly used in disease research. The scientists infected 1-day-old C57BL/6 mice with Zika virus and found that they develop symptoms of neurological disease, such as unsteady gait and seizures that gradually fade over two weeks.
The researchers compared their new mouse model with young mice that have immune system defects and are known to die several days after Zika infection. They found significant differences in disease progression, immune system response, and neurological effects between the two models.
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Funding: This work was partly funded by the FDA Medical Countermeasures Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
Citation: Manangeeswaran M, Ireland DDC, Verthelyi D (2016) Zika (PRVABC59) Infection Is Associated with T cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl/6 Mice. PLoS Pathog 12(11): e1006004. doi:10.1371/journal.ppat.1006004