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Compound from chicory reveals possible treatment strategy for neurodegenerative disorders

New research in The FASEB Journal suggests that chicoric acid mitigates lipopolysaccharide-induced amyloidogenesis and memory impairment by inhibiting the NFκB signal pathway in mouse models

Federation of American Societies for Experimental Biology

In a new research report published online in The FASEB Journal, scientists used mice to show that chicoric acid, a component of chicory, may help reduce memory impairment associated with Alzheimer's disease, and possibly other neurodegenerative diseases.

"Chicoric acid, a nutraceutical component of chicory, also exists extensively in Echinacea purpurea, lettuce, dandelion, and other edible plants and vegetables," said Xuebo Liu, Ph.D., a researcher involved in the work at the College of Food Science and Engineering, Northwest A&F University, in Yangling, China. "Chicoric acid mitigated lipopolysaccharide-induced amyloidogenesis and memory impairment via inhibiting NFκB signal pathway, suggesting that chicoric acid supplementation might be a plausible therapeutic intervention for neuroinflammation-related diseases such as Alzheimer's disease."

To reach their conclusions, Liu and colleagues used three groups of mice: a control group, a group that received lipopolysaccharide (LPS), and another group that received both LPS and chicoric acid (CA). Learning and memory capabilities were evaluated using two separate behavioral tests (Y-maze and Morris water maze) four hours after LPS injection. They found that the LPS-treated mice took a longer time to find the platform compared to the control group, whereas supplementation with CA significantly decreased the escape latency. Next, the hidden platform was removed to perform a probe trial. Compared with the control group, the mice stimulated by LPS swam across the entire pool and spent less time in the target quadrant, with a lower number of platform crossings. The mice treated with CA plus LPS exhibited a significant increase in the average time spent in the target quadrant, with more crossings of the platform.

"These are provocative findings, but with the caveat that the LPS regime is not likely a model of long-term memory impairment," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "But the possibility remains that chicoric acid could prove to be a beneficial human nutraceutical for overall memory acuity."

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Submit to The FASEB Journal by visiting http://fasebj.msubmit.net, and receive monthly highlights by signing up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is the world's most cited biology journal according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Qian Liu, Yuwei Chen, Chun Shen, Yating Xiao, Yutang Wang, Zhigang Liu, and Xuebo Liu. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. FASEB J. doi:10.1096/fj.201601071R ; http://www.fasebj.org/content/early/2016/12/22/fj.201601071R.abstract

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