Public Release: 

New tools developed to help clinicians predict risk of cardiovascular disease

Risk prediction models for 182 nations will help pinpoint those most at risk, even in resource-poor settings

Harvard T.H. Chan School of Public Health

Boston, MA - A new study led by Harvard T.H. Chan School of Public Health researchers provides powerful new tools to help clinicians around the globe predict their patients' 10-year risk of cardiovascular disease (CVD).

The researchers produced the first set of risk charts for 182 countries to predict future risk of fatal and non-fatal CVD events, including heart attack and stroke. These up-to-date charts will be useful everywhere, but particularly in low- and middle-income countries that lack locally-developed models to predict CVD risk, and in places where access to labs that can perform bloodwork is limited. Typically, blood tests are necessary to measure CVD risk factors such as blood sugar and lipids.

Previously available risk models and charts were applicable only to a few high-income countries or to regions. The complete set of new risk charts and the risk calculators are available online at http://www.globorisk.org.

The study will appear January 23, 2017 in Lancet Diabetes and Endocrinology.

"National and international guidelines recommend that physicians use risk prediction equations, usually in the form of risk charts, to predict which of their patients are at high risk for heart disease and stroke, and to suggest lifestyle modification or prescribe medication to lower their risk. These new risk charts, specifically calibrated for each country, remove major obstacles in applying risk-based strategies to prevent cardiovascular diseases," said Goodarz Danaei, assistant professor of global health at Harvard Chan School and senior author of the paper.

Cardiovascular diseases are the leading cause of death and disability worldwide, and more than three-quarters of CVD-related deaths occur in low- and middle-income countries. But identifying those at high risk of having a future cardiovascular event can be difficult in many countries because there are no reliable risk charts, and because calculating risk typically relies on measurements of blood sugar and lipids--which, in resource-poor settings, can make the assessment too costly or impractical.

The researchers set out to provide CVD risk prediction models geared toward each country. They developed two models: one that uses lab-based blood measurements (a "laboratory-based model"), and one that can be used in the absence of bloodwork (an "office-based model"). To generate the models, researchers used data from eight long-term studies in the U.S. and recalibrated the models by using data on CVD risk factor levels and CVD rates for each target country.

The study found that, between 85% and 99% of the time, the office-based risk prediction model worked as well as the laboratory-based model in characterizing CVD risk. However, among diabetes patients, the office-based model underestimated the risk noticeably.

The study also found that 10-year CVD risk was lower in high-income countries than in lower- and middle-income countries. The highest CVD risks were in countries in Central and Southeast Asia and in Eastern Europe. CVD risk also varied significantly across countries and across genders. For example, the proportion of people in high-income countries at high risk for CVD ranged from 1% for South Korean women to 42% for Czech men, and in low- and middle-income countries it ranged from 2% in Uganda for both men and women to 13% in Iranian men.

"Our results suggest that urgent action is needed to strengthen the primary health care system in many low- and middle-income countries to detect individuals at high risk of CVD and to provide lifestyle counseling or medications to lower their risk," said Peter Ueda, postdoctoral research fellow in the Department of Global Health and Population at Harvard Chan and lead author of the study.

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After the embargo lifts, the paper can be found here: http://www.thelancet.com/journals/landia/article/PIIS2213-8587(17)30015-3/fulltext

Other Harvard Chan authors of the study were Joshua Salomon, professor of global health, and Majid Ezzati, adjunct professor of global health.

This study was funded by the U.S. National Institutes of Health (NIH; NIDDK: 1R01-DK090435).

"Cardiovascular risk charts for 182 countries: application of laboratory-based and office-based risk scores to global populations," Peter Ueda, Mark Woodward, Yuan Lu, Kaveh Hajifathalian, Rihab Al-Wotayan, Carlos A. Aguilar-Salinas, Alireza Ahmadvand, Fereidoun Azizi, James Bentham, Renata Cifkova, Mariachiara Di Cesare, Louise Eriksen, Farshad Farzadfar, Trevor S. Ferguson, Nayu Ikeda, Davood Khalili, Young-Ho Khang, Vera Lanska, Luz León-Muñoz, Dianna Magliano, Paula Margozzini, Kelias P. Msyamboza, Gerald N. Mutungi, Kyungwon Oh, Sophal Oum, Fernando Rodríguez-Artalejo, Rosalba Rojas-Martinez, Gonzalo Valdivia, Rainford Wilks, Jonathan E. Shaw, Gretchen A. Stevens, Janne Tolstrup, Bin Zhou, Joshua A. Salomon, Majid Ezzati, Goodarz Danaei, Lancet Diabetes and Endocrinology, January 23, 2017, doi: 10.1016/S2213-8587(17)30016-5

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Harvard T.H. Chan School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory to people's lives--not only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at Harvard Chan School teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America's oldest professional training program in public health.

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