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Study identifies brain's connections which keep related memories distinct from each other

University of Bristol

The team studied the hippocampus and prefrontal cortex -- two regions of the brain critical to memory function -- as damage in these areas can induce severe memory loss.

However, both areas are connected by a complex network of direct and indirect pathways, and the challenge has been until now, how to identify the precise routes through which these brain regions interact in memory formation.

Researchers from Bristol's Schools of Physiology, Pharmacology and Neuroscience and Clinical Sciences used a new novel pharmacogenetic technique to deactivate specific neural pathways from the hippocampus to the prefrontal cortex in rats. They then tested the rats' memory for objects presented at specific points in time, and in specific locations, to model episodic memory function' in humans.

The team found that one pathway from the hippocampus controlled the 'temporal' aspects of the memory such as those which enable a subject to remember when they had encountered an object, while a separate pathway enabled subjects to remember an object's location.

They found that by deactivating specific neural pathways and preventing the hippocampus from talking to the prefrontal cortex, episodic memory function was significantly disrupted.

Professor Clea Warburton, said: "Episodic memory stores an individual's unique recollection of a specific event and is important for remembering significant events in our lives. This type of integrated memory is important in helping us to remember significant events in our lives, and works by linking different types of information.

"For example, even remembering routine things such as where we parked the car requires our brain to store and link different types of information. We must remember what kind of car we have, when, and where we parked it. Linking these different components of memory depends on clear communication between different brain regions which work together forming complex memory networks.

"These findings, reveal for the first time, an important aspect of memory function critical to episodic memory and could help with developing new therapeutics to aid memory loss."

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The work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC).

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