Dietary intervention could benefit heart health in those with muscular dystrophy. That's according to new research published in Experimental Physiology. If these findings are confirmed in humans, it could mean that off the shelf supplements could improve health and life expectancy.
Scientists from Iowa State University, Auburn University and the University of Montana in the United States found that supplementing the mice's food with quercetin (a flavonol found in many fruits, vegetables, leaves, and grains) improved biomedical outcomes, providing an inflammatory and antioxidant effect. To the groups' surprise, they also found that the quercetin-fed mice were more active than the control group
Duchenne Muscular Dystrophy (DMD) is a severe type of muscular dystrophy that causes a decline in cardiac health resulting in premature death, at an average age of 26 years. Duchenne's predominantly affects males.
The researchers used several mouse models for muscular dystrophy, carrying out experiments in parallel. By doing this they were able to replicate muscular dystrophy in humans as closely as possible.
Dr John C. Quindry, the corresponding author, said:
'A currently available dietary intervention could benefit those with muscular dystrophy. We gave the mice a quercetin dose that was proportional to those that could be given to humans. This allows the scientists to make the best possible connections between animal and human research findings'
Notes for Editors
1. Full paper title: Long term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice DOI: 10.1113/EP086091
Link to paper (link will only work after the embargo date. Before then please email the press office for a copy of the paper) http://onlinelibrary.
2. Experimental Physiology publishes translation and integration of research, specifically manuscripts that deal with both physiological and pathophysiological questions that investigate gene/protein function using molecular, cellular and whole animal approaches. http://ep.
3. The Physiological Society brings together over 3,500 scientists from over 60 countries. The Society promotes physiology with the public and parliament alike. It supports physiologists by organising world-class conferences and offering grants for research and also publishes the latest developments in the field in its three leading scientific journals, The Journal of Physiology, Experimental Physiology and Physiological Reports. http://www.
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John C. Quindry
University of Montana