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New understanding of chronic lung inflammatory diseases unfolding

Mary Ann Liebert, Inc./Genetic Engineering News

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Credit: Mary Ann Liebert, Inc., publishers

New Rochelle, NY, April 23, 2017--Researchers studying chronic inflammation that can lead to the development of lung diseases such as asthma, pulmonary fibrosis, and cancer, are focusing on the role cytokines play in regulating the behavior of fibroblast cells and the extracellular matrix. The most recent evidence on cytokine regulation of inflammatory disease in the lung is presented in a comprehensive review article published in Journal of Interferon & Cytokine Research (JICR) from Mary Ann Liebert, Inc., publishers. The article is available free on the JICR website until April 13, 2017.

In the article entitled "Innate Immune Cytokines, Fibroblast Phenotypes, and Regulation of Extracellular Matrix in Lung," Carl Richards, PhD, McMaster University, Hamilton, Canada, examines the scientific evidence suggesting that cytokines stimulated by the innate immune system can directly control fibroblast behavior. Fibroblasts are major contributors to extracellular remodeling and regulate the accumulation of inflammatory cells, which can lead to chronic inflammation and ultimately to organ dysfunction. Dr. Richards discusses the potential of metabolic changes, age, and epigenetic mechanisms to affect the activity of fibroblasts and immune system cell populations through impact on cytokine-mediated signaling pathways.

"Dr. Richards has made major contributions to our understanding of cytokine mediated effects on inflammatory disorders mediated through interactions between the immune system and resident fibroblasts," says Journal of Interferon & Cytokine Research Co-Editor-in-Chief Thomas Hamilton, Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH. "This review provides a highly relevant discussion of these issues and is particularly timely as our ability to use this knowledge is enabling new therapeutic strategies to treat inflammation-related chronic disease."

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About the Journal

Journal of Interferon & Cytokine Research (JICR), led by Co-Editors-in-Chief Ganes C. Sen, PhD and Thomas A. Hamilton, PhD, Department of Immunology, Cleveland Clinic Foundation, is an authoritative peer-reviewed journal published monthly online with open access options and in print that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is an official journal of the International Cytokine & Interferon Society. Complete tables of content and a sample issue may be viewed on the JICR website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Viral Immunology, AIDS Research and Human Retroviruses, and DNA and Cell Biology. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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