Public Release: 

Newly discovered virus affects sex ratio of insect-killing wasps

A higher proportion of male wasps could promote widespread virus transmission, scientists speculate

PLOS

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IMAGE: Vertical transmission of PpNSRV-1 in Pteromalus puparum wasps (A) and viral detection in field populations of Pteromalus puparum wasps (B). view more

Credit: Wang F, et al. (2017)

Scientists have identified a previously unknown virus that decreases the number of female offspring of the wasps it infects, according to a PLOS Pathogens study. The virus, discovered by Gongyin Ye's group of Zhejiang University, infects one species of a specific group of wasps known as parasitoid wasps.

Parasitoid wasps lay their eggs inside the bodies of the host insects. After the eggs hatch, the young wasps spend the first part of their life cycle feeding on the host insect until it dies. Many parasitoid wasps have symbiotic relationships with viruses that enable wasps to produce substances that weaken the host insect immune defense and help the wasps survive.

While studying a parasitoid wasp species known as Pteromalus puparum, Ye's team discovered signs of a virus among products of the wasp's transcriptome. They sequenced the viral genome and found that it belonged to a previously unknown species. The virus, dubbed PpNSRV-1 represents a novel genus of the taxonomic order Mononegavirales, making it the first virus of that genus to be found in parasitoid wasps.

After identifying PpNSRV-1, the researchers investigated its influence on infected wasps. They compared wasps infected by PpNSRV-1 with non-infected wasps and found that the virus lengthens the lifespan of the wasps. The scientists hypothesize that this could help the virus by giving wasps more time to transmit the virus to more hosts.

PpNSRV-1 also reduces the number of female offspring produced by the wasp. The scientists speculate that a reduced number of female offspring could also promote viral transmission. This is because both males and female wasps appear to be able to pass PpNSRV-1 to offspring, and since males can mate with multiple females, a higher ratio of males could spread the virus farther. It is first reported that the virus associated with parasitoid wasps has the key role in regulating wasp offspring sex ratio before which only bacterial symbionts such as Wolbachia are considered to be related to regulate its host wasp sex ratio.

Much more research is needed to better understand PpNSRV-1 and its full impact on wasps. For example, while the virus may extend wasp lifespan in the lab, it may not do so in nature. Better understanding of parasitoid wasps in general is useful since their insect-killing tendencies make some of them valuable for insect control in agriculture.

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In your coverage please use this URL to provide access to the freely available article in PLOS Pathogens: http://dx.doi.org/10.1371/journal.ppat.1006201

Citation: Wang F, Fang Q, Wang B, Yan Z, Hong J, Bao Y, et al. (2017) A novel negative-stranded RNA virus mediates sex ratio in its parasitoid host. PLoS Pathog 13(3): e1006201. doi:10.1371/journal.ppat.1006201

Funding: FW, QF, BW, ZY and GY were supported by grants from Major International (Regional) Joint Research Project of National Natural Science Foundation (Grant no. 31620103915, China National Program on Key Basic Research Projects (973 Program, Grant no. 2014CB138400, 2013CB127600, National Natural Science Foundation of China (Grant no.31272098, 31472038 , and China National Science Fund for Distinguished Young Scholars (Grant no. 31025021. JHW's contributions were supported by National institutes of health Research Project Grant Program (R01-GM098667). This work was supported in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. A subcontractor to Battelle Memorial Institute who performed this work is: JHK, an employee of Tunnell Government Services, Inc. YB was supported by the Intramural Research Program of the NIH, National Library of Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: JHK was initially assigned as an Editor on this paper. After a revise decision was returned, the authors contacted Dr. Kuhn to propose collaborating on the revision due to his expertise on this topic. Dr. Kuhn agreed, and therefore recused himself from further editorial involvement. The authors declare that no further competing interests exist.

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