PHILADELPHIA - A new analysis of patients who have undergone treatment for prostate cancer shows a connection between androgen deprivation therapy (ADT) -- a testosterone-lowering therapy and a common treatment for the disease -- and dementia, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. Their previous studies have shown men who undergo ADT may be at an increased risk of dementia, including Alzheimer's disease, compared to men who were not treated with the therapy. This new analysis -- the largest of its kind ever performed on this topic -- shows that all existing studies taken together support the link to dementia and show a possible link to Alzheimer's. The findings are published this week in Prostate Cancer and Prostatic Diseases. "Since publishing our initial findings, there has been a lot of other research on this topic, and we wanted to see what that research was saying," said the study's lead author Kevin Nead, MD, MPhil, a resident in Radiation Oncology at Penn. "This analysis tells us that the composite message of existing studies is that androgen deprivation therapy is associated with dementia."
The team compiled data from four different global databases looking at studies on ADT patients and dementia and Alzheimer's. An analysis of more than 50,000 patients worldwide showed a consistent statistical link between men who underwent ADT for prostate cancer and men who developed dementia. Nead says the numbers show correlation, not causation at this point, but that there is evidence of a direct connection.
"Research shows androgens play a key role in neuron maintenance and growth, so the longer you undergo this therapy to decrease androgens, the more it may impact the brain's normal functions," Nead said.
The analysis was less conclusive on the question of Alzheimer's. While there was still a connection, it was not as clearly defined as the link to dementia. Nead says evidence for a link between ADT and neurocognitive dysfunction is growing and should be part of the conversation between doctors and patients.
"There's enough evidence of these links that patients should know about them when considering their options," Nead said.
Nead's work is supported in part by his membership in the American board of Radiology Holman Research Pathway.
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