Zika virus can persist in cerebrospinal fluid (CSF), lymph nodes and colorectal tissue of infected rhesus monkeys for weeks after the virus has been cleared from blood, urine and mucosal secretions, according to a study published online in Cell. The research was led by Dan H. Barouch, M.D., Ph.D., and colleagues at Beth Israel Deaconess Medical Center and Harvard Medical School and was funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
Investigators infected 20 rhesus monkeys with Zika virus and noted that although virus was cleared from peripheral blood within 7-10 days, it was detected in CSF for up to 42 days and in lymph nodes and colorectal tissue for up to 72 days. Immunologic data showed that the emergence of Zika virus-specific neutralizing antibodies correlated with the rapid control of the virus in plasma. However, Zika-specific antibodies were not detected in CSF, which could be why the virus remained there longer. The authors also found that viral persistence in CSF correlated with the activation of the mechanistic target of rapamycin (mTOR) pathway, which has been shown to be related to the development of brain tissue and brain malformations.
The findings suggest that persistent virus in the central nervous system may contribute to the neurological issues associated with Zika virus infection in people, the authors note. Although Zika virus usually causes mild or no symptoms in people, it has been associated with neurological disorders in children and adults and can cause severe fetal defects, such as microcephaly, if an infected pregnant woman passes the virus to her fetus. The authors note that if the virus can persist in the central nervous system and other tissues in humans with Zika infection, more extensive neurologic and lymphoid disease than currently appreciated may be occurring.
M Aid et al. Zika virus persistence in the central nervous system and lymph nodes of Rhesus monkeys. Cell DOI: 10.1016/j.cell.2017.04.008 (2017).
NIAID Director Anthony S. Fauci, M.D., is available for comment. Cristina Cassetti, Ph.D., acting chief, Virology Branch, Division of Microbiology and Infectious Diseases, NIAID, is also available for comment.
To schedule interviews, please contact Jennifer Routh, (301) 402-1663, email@example.com.
NIAID conducts and supports research -- at NIH, throughout the United States, and worldwide--to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.
NIH...Turning Discovery Into Health®