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Conscious sedation is a safe alternative to general anesthesia for heart valve procedure

University of California - Los Angeles Health Sciences

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IMAGE: Rendering of a heart valve inserted during transcatheter aortic valve replacement. A UCLA study found that keeping patients awake but sleepy during the procedure is preferable to general anesthesia. view more

Credit: Courtesy of Edwards Lifesciences

FINDINGS

UCLA scientists have found that conscious sedation -- a type of anesthesia in which patients remain awake but are sleepy and pain-free -- is a safe and viable option to general anesthesia for people undergoing a minimally invasive heart procedure called transcatheter aortic valve replacement.

In the study, patients who underwent conscious sedation had a similar rate of adverse events to those who underwent anesthesia, but those who were given conscious sedation had shorter stays in the intensive care unit (30 versus 96 hours for those with general anesthesia) and shorter hospital stays (4.9 days versus 10.4 days). The direct costs for their care were 28 percent lower, and almost all other medical costs were lower as well. In both groups, 1.5 percent of patients died during hospitalization.

BACKGROUND

Aortic stenosis is a common disease, particularly among people 75 and older, in which one of the valves of the heart narrows and impedes blood flow to the body. Previously, treating aortic stenosis required open heart surgery, which is particularly risky for elderly and frail patients.

In recent years, the use of transcatheter aortic valve replacement, or TAVR, has made the repair safer: Physicians place a new valve in the heart via a catheter inserted through the patient's leg, which results in less injury and an easier recovery than open heart surgery. Most medical centers perform the procedure under general anesthesia but some, including UCLA, now offer their patients conscious sedation, which does not require a breathing tube.

METHOD

The study was the first to detail the cost differences and outcomes between conscious sedation and general anesthesia during transcatheter aortic valve replacement. Researchers analyzed records of 196 adult patients who underwent transcatheter aortic valve replacement at Ronald Reagan UCLA Medical Center between August 2012 and June 2016. The researchers write that a large-scale, controlled and randomized study should be conducted to validate their findings.

IMPACT

Based on the study, patients undergoing transcatheter aortic valve replacement should receive conscious sedation instead of general anesthesia whenever possible.

AUTHORS

The study was led by Dr. Richard Shemin, the Robert and Kelly Day Professor of Surgery and chief of cardiac surgery at the David Geffen School of Medicine at UCLA and Dr. Peyman Benharash, an assistant professor of cardiothoracic surgery at the David Geffen School of Medicine at UCLA. Other authors are William Toppen, Daniel Johansen, Sohail Sareh, Josue Fernandez, Nancy Satou, Dr. Komal Patel, Dr. Murray Kwon, Dr. William Suh, and Dr. Olcay Aksoy, all of UCLA.

JOURNAL

The study was published online April 5 in the journal PLOS ONE.

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