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The fascinating molecule linking hydration and health

Charles Bourque from McGill University finds a new role for vasopressin as an anticipatory neurological signal of dehydration in the brain

Canadian Association for Neuroscience

Water is the single greatest need for life. Despite this requirement, the amount of liquid we have in our bodies is controlled by only one molecule. It's known as vasopressin and today, Dr. Charles Bourque from McGill University revealed some unexpected ways this chemical ensures we stay properly hydrated. His results were presented at the 2017 Canadian Neuroscience Meeting, the annual meeting of the Canadian Association for Neuroscience - Association Canadienne des Neurosciences (CAN-ACN).

Vasopressin has been known for seventy years as a hormonal controller of hydration. Yet until recently it was thought only to be involved in reacting to water levels. As Bourque notes, "We always thought of vasopressin as the classic negative feedback system. When we are dehydrated, its concentration goes up. If we have too much water in your body, the concentration declines."

But Bourque's research has revealed this molecule is full of surprises. "It's also involved in feed-forward mechanisms," he says. "We determined this molecule is produced in the brain right before you go to bed and during sleep in anticipation of the dehydrating effect of sleep" These new functions reveal the molecule is acting not only as a hormone, but also as a neurological signal.

Bourque indicated that many common health problems are linked to inappropriate changes in vasopressin. "We've known for some time that it is involved in critical conditions like congestive heart failure and some types of lung cancer and other ailments like bed-wetting or increased urination at night. Our recent work has shown it also plays a key role in salt-dependent hypertension". Bourque stated that body fluid disorders are among the top 10 reasons for patient admission to Emergency Departments at US hospitals.

As a result of his work, Bourque believes public health needs to take a more proactive approach to vasopressin. "We know it is one of the most important molecules for regulating body hydration, but we still can't use it to improve primary care." He hopes to work in collaboration with other researchers to develop sensitive tests for hospitals and emergency workers. "Given the importance of this molecule, it would be useful to have rapid measurements of vasopressin to better understand how the body is handling water. It may even give us the upper hand in dealing with several acute and chronic illnesses."


This research was supported by the Canadian Institutes of Health Research (CIHR) and the Heart and Stroke Foundation of Canada.

About the Canadian Association for Neuroscience:

The Canadian Association for Neuroscience is the largest association dedicated to the promotion of all fields of neuroscience research in Canada. The association has been organizing a yearly annual meeting since 2007. Learn more about our meeting at: http:/

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