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Study examines palliative care trends in patients with end-stage liver disease


A new study has uncovered low rates of referral for palliative care in US patients with end-stage liver disease, although rates have been slowly increasing over time. The Hepatology study also found that certain socioeconomic and ethnic barriers may hinder access to palliative care services.

Individuals with end-stage liver disease, an illness that can develop after the progression of chronic liver disease to advanced liver fibrosis and cirrhosis, often experience numerous symptoms. Historically, only a limited number of affected patients have used palliative care, which is focused on providing relief from the symptoms and stress of a serious illness, with the ultimate goal of improving quality of life.

To investigate trends in the use of palliative care services in patients with end-stage liver disease hospitalized across the United States, a team led by Mayur Brahmania, MD, of Toronto General Hospital, University Health Network, analyzed information from the 2006-2012 National Inpatient Sample, a database that captures approximately 20% of all in-patient hospitalizations from 46 states.

Of 39,349 patients in the analysis, palliative care consultations were performed for 1789 (4.5%) of patients. The rate of palliative care referral increased from 0.97% in 2006 to 7.1% in 2012. Hispanic race and lower socio-economic status were linked with lower palliative care referrals.

"The current study is one of the largest nationwide studies of palliative care referral in patients with end-stage liver disease. Although palliative care referrals in patients with end-stage liver disease is increasing, the rate of referrals is still very low," said Dr. Brahmania. "We must emphasize that palliative care is an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and treatment of pain along with other physical and psychosocial issues."

Dr. Brahmania noted that there has traditionally been very little guidance for the use of palliative care in the setting of end-stage liver disease given the variable course of the disease, patients not appearing 'sick', or a lack of recognition of symptoms; however, palliative care is of significant value as patients experience an improvement in quality of life and better alignment of goals with their medical care. "We feel early concurrent palliative care could significantly benefit the patient with end-stage liver disease and practitioners providing this care must find ways to integrate palliative care with the possibility of life-prolonging therapy."


Additional Information

Article: "Palliative Care Access for Hospitalized Patients with End Stage Liver Disease Across the United States." Barret Rush, Keith R. Walley, Leo Anthony Celi, Neil Rajoriya, and Mayur Brahmania. Hepatology; Published Online: June 29, 2017 (DOI: 10.1002/hep.29297).

Link to Study:

About the Journal Hepatology is the premier publication in the field of liver disease, publishing original, peer-reviewed articles concerning all aspects of liver structure, function and disease. Each month, the distinguished Editorial Board monitors and selects only the best articles on subjects such as immunology, chronic hepatitis, viral hepatitis, cirrhosis, genetic and metabolic liver diseases and their complications, liver cancer, and drug metabolism. Hepatology is published on is published by Wiley on behalf of the American Association for the Study of Liver Diseases (AASLD). For more information, please visit

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