WINSTON-SALEM, N.C. - June 27, 2017 - Moderate-intensity exercise can help even extremely obese older adults improve their ability to perform common daily activities and remain independent, according to researchers at Wake Forest Baptist Medical Center.
Findings from the National Institutes of Health-funded study are published in the July issue of the journal Obesity.
In the United States, obesity affects nearly 13 million adults age 65 and older. Both overall obesity and abdominal obesity are strongly associated with the development of major mobility disability (MMD), the inability to walk a quarter of a mile, according to the study's lead author, Stephen Kritchevsky, Ph.D., director of the Sticht Center for Healthy Aging and Alzheimer's Prevention at Wake Forest Baptist.
Previous data on older populations had suggested that obesity may lessen the beneficial effects of physical activity on mobility. However, this research, which analyzed data from the multicenter Lifestyle Interventions and Independence for Elders (LIFE) study, showed that a structured physical activity program reduced the risk of MMD even in older adults with extreme obesity.
"The inability to walk a quarter of a mile is a proxy for common daily activities, such as the inability to walk a block around the neighborhood or to walk several street blocks to go to a store," Kritchevsky said. "Having a major mobility disorder can really affect the quality of life and independence for older people, but we showed that moderate exercise was a safe and effective way to reduce that risk even in severely obese people."
The LIFE study was a large clinical trial that enrolled 1,635 sedentary men and women age 70 to 89. The participants were randomized to a moderate intensity physical activity program or a health education program to test if the physical activity program would reduce the rate of MMD compared to the education program. Major mobility disability was defined as the inability to walk 400 meters (about a quarter of a mile) without sitting and without help from another person or a walker, Kritchevsky said.
Participants were divided into four groups according to body mass index (BMI) - a measure of body fat based on height and weight - and waist circumference: non-obese with BMI less than 30; non-obese with high waist circumference of more than 40 inches for men and 34 inches for women; class 1 obese with BMI between 30 and 35; and class 2 obese with BMI of 35 or higher.
The physical activity program focused on walking, strength, balance and flexibility training. The goal for participants was to be able to walk at moderate intensity for 30 minutes and perform 10 minutes of lower-extremity strength training with ankle weights and 10 minutes of balance training in a single session. Participants attended two center-based training sessions per week and performed at-home activities three to four times per week during the two-year study.
The health education program involved in-person group workshops focused on aging-relevant topics such as nutrition, safety and legal/financial issues. Sessions included lectures and interactive discussions and five to 10 minutes of upper body stretching exercises.
While there was no significant difference between obesity category and intervention effect, those in the class 2 obesity group showed the greatest benefit from the physical activity program, reducing their risk of MDD by 31 percent, Kritchevsky said.
The LIFE study was the first to demonstrate that moderate intensity physical activity can significantly reduce the risk of MMD in sedentary older adults.
Co-authors are: Laura Lovato, M.S., and Elizabeth P. Handing, Ph.D., Wake Forest Baptist; Steven Blair, P.E.D., University of South Carolina; Anda Botoseneau, M.D., University of Michigan; Jack M. Guralnik, M.D., University of Maryland School of Medicine; Christine Liu, M.D. Boston University School of Medicine; Abby King, Ph.D., Stanford University School of Medicine; Anthony P. Marsh, Ph.D., and W. Jack Rejeski, Ph.D., Wake Forest University; Marco Pahor, M.D., and Todd Manini, Ph.D., University of Florida College of Medicine; and Bonnie Spring, Ph.D., Northwestern University Feinberg School of Medicine.
The LIFE study was funded by a National Institutes of Health/National Institute on Aging Cooperative Agreement UO1 AG22376 and a supplement from the National Heart, Lung and Blood Institute 3U01AG022376-05A2S, and sponsored in part by the Intramural Research Program, National Institute on Aging. The research was partially supported by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (1 P30 AG028740), Wake Forest University (1 P30 AG21332), Tufts University (1P30AG031679), University of Pittsburgh (P30 AG024827) and Yale University (P30AG021342) and the NIH/NCRR CTSA at Stanford University (UL1 RR025744), Tufts University is also supported by the Boston Rehabilitation Outcomes Center (1R24HD065688-01A1).