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Google searches can be used to track dengue in underdeveloped countries

Near real-time monitoring could enable faster response to outbreaks

PLOS

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IMAGE: The dengue virus is transmitted to people primarily through the bite of an infected Aedes aegypti mosquito. Originally from Africa, these mosquitoes are now found in tropical and subtropical regions... view more 

Credit: James Gathanay, CDC

An analytical tool that combines Google search data with government-provided clinical data can quickly and accurately track dengue fever in less-developed countries, according to new research published in PLOS Computational Biology by Shihao Yang of Harvard University and colleagues.

The research builds on a methodology previously developed by the team to track influenza in the United States. This mathematical modeling tool, known as "AutoRegression with GOogle search queries" (ARGO), revived hopes in 2015 that internet search data could help health officials track diseases after earlier systems like Google Flu Trends and Google Dengue Trends returned poor results.

In the new study, the research team modified ARGO to explore its potential to track dengue activity in Mexico, Brazil, Thailand, Singapore, and Taiwan. Dengue, a mosquito-borne virus that infects about 390 million people each year, is often difficult to monitor with traditional hospital-based reporting due to inefficient communication, but dengue-related Google searches could provide faster alerts.

The researchers used Google's "Trends" tool to track the top ten dengue-related search queries made by users in each country during the study period. They also gathered historical dengue data from government health agencies and input both datasets into ARGO. Using the assumption that more dengue-related searches occur when more people are infected, ARGO calculated near real-time estimates of dengue prevalence for each country.

The scientists then compared ARGO's estimates with those from five other methods. They found that ARGO returned more accurate estimates than did any other method for Mexico, Brazil, Thailand, and Singapore. Estimates for Taiwan were less accurate, possibly because the country experienced less-consistent seasonal disease patterns from year to year.

The findings highlight the potential for Google searches to enable accurate, timely tracking of mosquito-borne diseases in countries lacking effective traditional surveillance systems. Future work could investigate whether this method could be improved to track disease on finer spatial and temporal scales, and whether environmental data, such as temperature, could improve estimates.

"The wide availability of internet throughout the globe provides the potential for an alternative way to reliably track infectious diseases, such as dengue, faster than traditional clinical-based systems," says study senior author Mauricio Santillana of Boston Children's Hospital and Harvard Medical School. "This alternative way of tracking disease could be used to alert governments and hospitals when elevated dengue incidence is anticipated, and provide safety information for travelers."

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In your coverage please use this URL to provide access to the freely available article in PLOS Computational Biology: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005607

Citation: Yang S, Kou SC, Lu F, Brownstein JS, Brooke N, SantillanaM (2017) Advances in using Internet searches to track dengue. PLoS Comput Biol 13(7): e1005607. https://doi.org/10.1371/journal.pcbi.1005607

Funding: SY, FL, and MS were supported by a grant from the the Synergist, award 01-2016. SCK's research is supported in part by NSF grant DMS-1510446. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

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