A new five-year federal research grant totaling $2,317,760 will fund studies by Jackson Laboratory (JAX) Assistant Professor Duygu Ucar, Ph.D., into the mechanisms that cause the immune system to decline with age.
"As we age," Ucar says, "the immune system, which protects the body from infections and tumors, loses strength. The wide-ranging health consequences of this include increased vulnerability to bacteria such as pneumococcal pneumonia, vaccines working less well, and individuals becoming more susceptible to some cancers."
The declining responsiveness of the aging immune system to combat infection is a major threat to the health, independence and survival of older adults, she notes. With the new funding from the National Institute of General Medical Sciences, Ucar will investigate the regulatory mechanisms behind the functional decline of the human immune system with aging. She will also explore how men and women age differently and look for biomarkers of healthy aging.
The Ucar laboratory develops computational tools to uncover complex regulatory programs in blood-derived human immune cells associated with aging, in collaboration with clinicians, immunologists and chromatin scientists.
Chromatin shapes our DNA's three-dimensional structure, and consists of DNA, proteins called histones and RNA. Every cell type has a characteristic chromatin structure, which dictates the functionality of this cell. With aging the chromatin structure goes through major changes that impair cell functions and lead to genomic instability. With this new grant, Ucar will investigate which genes, proteins and other regulatory elements are affected by these changes, using the latest genomics technologies and developing novel computational methods.
The Jackson Laboratory is an independent, nonprofit biomedical research institution based in Bar Harbor, Maine, with a National Cancer Institute-designated Cancer Center, a facility in Sacramento, Calif., and a genomic medicine institute in Farmington, Conn. It employs 1,900 staff, and its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
Identification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune Cells, National Institute of General Medical Sciences, grant #1R35GM124922-01