Public Release: 

Predicting atypical development in infants at high risk for autism?

Columbia University Medical Center

New York, NY, (Sept. 12, 2017) - New research from the Sackler Institute for Developmental Psychobiology at Columbia University Medical Center (CUMC) identifies a potential biomarker that predicts atypical development in 1- to 2-month-old infants at high versus low familial risk for developing autism spectrum disorders (ASD). The search for neurobiological markers that precede atypical trajectories is important in infants with a high risk for developing autism-related disorders because early recognition allows for early intervention and mitigation of difficulties later in life.

Using data from National Database for Autism Research (NDAR), lead author Kristina Denisova, PhD, Assistant Professor of Psychiatry at CUMC and Fellow at the Sackler Institute, studied 71 high and low risk infants who underwent two functional Magnetic Resonance imaging brain scans either at 1-2 months or at 9-10 months: one during a resting period of sleep and a second while native language was presented to the infants. After extracting measures of head movements during the scans, the statistical characteristics of these movements were quantified.

The study found that infants at high risk for developing ASD have elevated levels of "noise" and increased randomness in their spontaneous head movements during sleep, a pattern possibly suggestive of problems with sleep. In addition, 1- to 2-month-old high risk infants showed more similar signatures while listening to native language and while sleeping while low risk infants showed distinct signatures during the two conditions.

Further, specific features of head movements during sleep at 1-2 months predicted future flatter (delayed) early learning developmental trajectories in the high-risk babies. The existence of generally atypical learning trajectories in the high risk group was verified in separate data sets from four representative high risk infant-sibling studies comprising a total of 1,445 infants with known ASD outcomes as children. These analyses showed that high risk infants -- even those without ASD diagnoses -- have significantly lower functioning in childhood relative to low risk infants. The current study reveals a possible way to predict which 1-2 months-old infants will show atypical developmental trajectories as toddlers.

Dr. Denisova said, "The finding that head movement signatures are responsive to high context stimuli (native language speech) in low but not high risk infants is informative because it suggests that infants whose siblings were diagnosed with ASD are less attuned to evolutionarily important stimuli early in life." She added that this response pattern may underlie atypical information processing in individuals with neurodevelopmental disorders.

Dr. Jeremy Veenstra-VanderWeele, MD, an autism researcher who was not involved in this study, noted, "This study is a good example of how existing data can be mined for new insights. Additional work is needed to replicate the current findings and understand the underlying mechanisms, but this work suggests new ways to look at movement or motor function in infants at high risk of ASD."

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The paper, "Inflexible neurobiological signatures precede atypical development in infants at high risk for autism," was published in Nature Scientific Reports September 12, 2017. The authors are Kristina Denisova, PhD (Sackler Institute for Developmental Psychobiology and Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY) and Guihu Zhao, PhD (Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY).

This work was supported by a Sackler Award in Developmental Psychobiology to Kristina Denisova.

The authors report no financial or other conflicts of interest.

Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. The campus that Columbia University Medical Center shares with its hospital partner, NewYork-Presbyterian, is now called the Columbia University Irving Medical Center. For more information, visit cumc.columbia.edu or columbiadoctors.org.

Columbia University Department of Psychiatry

Columbia Psychiatry is among the top ranked psychiatry departments in the nation and has contributed greatly to the understanding and treatment of brain disorders. Co-located at the New York State Psychiatric Institute on the NewYork-Presbyterian Hospital/Columbia University Medical Center campus in Washington Heights, the department enjoys a rich and productive collaborative relationship with physicians in various disciplines at Columbia University's College of Physicians and Surgeons. Columbia Psychiatry is home to distinguished clinicians and researchers noted for their clinical and research advances in the diagnosis and treatment of depression, suicide, schizophrenia, bipolar and anxiety disorders, eating disorders, substance use disorders, and childhood psychiatric disorders.

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