Public Release: 

Acute kidney failure with VTE proves difficult to treat

American College of Chest Physicians

TORONTO (October 23, 2017) -Researchers from the Walter Reed National Military Medical Center conducted a prospective, observational study to assess the impact that weight and renal function have on venous thromboembolism (VTE) rates among in-patients receiving prophylaxis with low-molecular-weight or unfractionated heparin.

Between September 2009 and 2011, 6599 patients were admitted to the hospital for at least two days. The mean age and body mass index (BMI) were 54.6 and 28.5, respectively. Among those who developed VTE, 165 (71.1%) were diagnosed during admission, 27 (11.7%) within 30 days, and 7.2% between 30 and 90 days after admission.

They concluded that a person's body mass index (BMI) was not related to VTE rates, but renal function did have an impact. Creatinine clearance was not associated with VTE rates when unfractionated heparins or low-molecular weight heparins were given, but patients with acute kidney injury had higher VTE rates, even in the presence of prophylaxis.

"Current unfractionated and low-molecular-weight heparin dosing in the presence of acute kidney injury may not be sufficient to prevent VTE," warns lead researcher Dr. Aaron Holley, "future studies need to address the optimal dosing of heparins in these cases."

Further results from this study will be shared at the CHEST Annual Meeting 2017 in Toronto on Tuesday, October 31, 11:30 AM-11:45 AM at the Metro Toronto Convention Centre, Room 606. The study abstract can be viewed on the journal CHEST® website.



CHEST 2017 is the 83rd annual meeting of the American College of Chest Physicians, held October 28-November 1, 2017, in Toronto, Ontario. The American College of Chest Physicians, publisher of the journalCHEST®, is the global leader in advancing best patient outcomes through innovative chest medicine education, clinical research, and team-based care. Its mission is to champion the prevention, diagnosis, and treatment of chest diseases through education, communication, and research. It serves as an essential connection to clinical knowledge and resources for its 19,000+ members from around the world who provide patient care in pulmonary, critical care, and sleep medicine. For more information about CHEST 2017, visit, or follow CHEST meeting hashtag, #CHEST2017, on social media.

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