New Rochelle, NY, Oct. 24, 2017 -- Novel approaches to tissue engineering and regenerative medicine are first evaluated and optimized in animal models before making the leap to clinical testing in human subjects. For many of these innovative new techniques and materials to succeed and advance to the clinic, the selection of an appropriate animal model and design of the experiments to gauge performance and outcomes can determine whether a particular approach, and the field in general, continue to move forward. A special issue devoted to the latest research on using animal models in regenerative medicine research is forthcoming in Tissue Engineering, Part C, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Select articles from the issue are now available online on the Tissue Engineering website.
Guest Editors Jorge Piedrahita, PhD, North Carolina State University College of Veterinary Medicine, Raleigh, and J. Koudy Williams, DVM, Wake Forest School of Medicine, Winston Salem, NC oversaw the development of the special issue. They compiled a series of outstanding papers on diverse topics contributed by leading researchers. These include the article entitled "Inflammation-Induced Osteogenesis in a Rabbit Tibia Model," in which F. Cumhur Öner, MD, PhD, et al., University Medical Center Utrecht, Delft University of Technology, and Utrecht University, The Netherlands, examined the inflammatory responses to bacterial infection that can promote bone formation. The researchers showed that the inflammatory response caused by exposure to Staphylococcus aureus antigens, in the absence of bacterial infection, could stimulate bone growth and might be a useful strategy in bone regenerative medicine.
In the article "Rise of the Pigs: Utilization of the Porcine Model to Study Musculoskeletal Biomechanics and Tissue Engineering During Skeletal Growth," Matthew Fisher, PhD and coauthors from North Carolina State University, University of North Carolina at Chapel Hill and UNC School of Medicine, present the unique opportunities and challenges for using pigs as translational models in the development of musculoskeletal regenerative medicine approaches. In particular, the researchers describe the advantages porcine models offer for studying biomechanics.
Johan Lammens, MD, PhD and coauthors from University Hospitals KU Leuven, KU Leuven, Medanex Clinic (Diest), and University of Liège, Belgium, caution that techniques for repairing large bone defects developed in the laboratory will only ultimately be successful in humans if the preclinical studies are performed in a reliable animal model using a bone defect of sufficient size created by following well-defined methods. They share their perspectives in the article entitled "Warning About the Use of Critical-Size Defects for the Translational Study of Bone Repair: Analysis of a Sheep Tibial Model."
"This special issue emphasizes not only the need for appropriate animal models to increase our understanding and knowledge, but also for the final clinical application of regenerative medicine-based products," says Methods Co-Editor-in-Chief John A. Jansen, DDS, PhD, Professor and Head, Department of Biomaterials, Radboud University Medical Center, The Netherlands.
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Research reported in this publication was supported by the National Institutes of Health under Award Number R03AR068112. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
About the Journal
Tissue Engineering is an authoritative peer-reviewed journal published 42 times per year online and in print in three parts: Part A, the flagship journal, published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Leadership of Tissue Engineering Parts B (Reviews) and Part C (Methods) is provided by John P. Fisher, PhD, University of Maryland and John A. Jansen, DDS, PhD, Radboud University, respectively. Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on the Tissue Engineering website.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.