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The brain auditions different cells when learning a task, some don't make the cut

Cell Press

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IMAGE: This is a schematic illustration of potential cellular changes underlying gray matter volume expansion and renormalization as detectable with MRI. view more 

Credit: Wenger et al./Trends in Cognitive Sciences 2017

For decades, neuroscientists have wondered how the brain can continue to learn new skills without needing to grow in size or volume over a person's lifetime. Evidence suggests that the number of brain cells - such as neurons and glial cells - does initially increase as we're learning, but many are eventually pruned away or assigned to other roles. Researchers in Germany and Sweden present this theory November 14 in the review journal Trends in Cognitive Sciences.

"Brain matter volume increases in the initial stages of learning, and then renormalizes partially or completely," says first author Elisabeth Wenger, a neuroscientist at the Max Planck Institute for Human Development in Berlin. "This seems to be an effective way for the brain to first explore the possibilities, call in different structures and cell types, select the best ones, and get rid of the ones that are no longer needed."

She describes brain cells as actors auditioning for a movie for which the brain is the director: The brain calls in the candidates by forming new cells, and this causes it to grow macroscopically in volume. The brain then tries out different functions for them--seeing which can store or carry the information best. Based on which cells function most efficiently, the brain dismisses the other candidates or assigns them to different roles.

As evidence, the researchers discuss a study in which right-handed people learned to write and draw with their left hands. After a month, their brain volume had increased, but three weeks later it was nearly back to normal. Researchers observed similar results in other studies in which monkeys learned to use a rake to retrieve food or rats learned to differentiate between sounds.

Wenger and her co-authors, including Claudio Brozzoli, Ulman Lindenberger, and Martin Lövdén, were surprised by how often the phenomenon of brain expansion and renormalization has been recorded already in animal studies, and predict it applies to human brains too. "We are definitely not the first to suggest or introduce the expansion-renormalization model," says Wenger. "I think we are just the ones who are now promoting it in the field of grey matter volume changes in humans."

The researchers believe that this theory should influence how researchers design neural studies. "In a way, it is now apparent that the typical design is just insufficient to show the full scope of changes that happen," Wenger says. "This theory calls for study designs with more measurement time points to properly display changes in brain volume."

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This work was supported by the Max Planck Society, European Research Council, the Swedish Research Council, the European University Institute, and the Agence Nationale de la Reserche.

Trends in Cognitive Sciences, Wenger et al.: "Expansion and Renormalization of Human Brain Structure During Skill Acquisition" http://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(17)30196-1

Trends in Cognitive Sciences (@TrendsCognSci), published by Cell Press, is a monthly review journal that brings together research in psychology, artificial intelligence, linguistics, philosophy, computer science, and neuroscience. It provides a platform for the interaction of these disciplines and the evolution of cognitive science as an independent field of study. Visit: http://www.cell.com/trends/cognitive-sciences. To receive Cell Press media alerts, please contact press@cell.com.

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