WASHINGTON -- Women who undergo hormone therapy to relieve menopausal symptoms tend to have less fat tissue, particularly in the abdomen, than other menopausal women, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.
Menopause is the process a woman goes through when her monthly periods end following the aging of the ovaries and the subsequent reduction of estrogens, the feminine sex hormone. Women going through this transition often find they are more susceptible to weight gain, and scientists are still researching how to improve this transition.
"When we studied a large sample of women to better understand the effect of menopausal hormone therapy on body composition, our research revealed that women were less likely to accumulate abdominal fat tissue while they were undergoing menopausal hormone therapy," said Georgios E. Papadakis, M.D., F.M.H., of Service of Endocrinology, CHUV, Lausanne University Hospital in Lausanne, Switzerland. "However, the protective effect disappeared quickly after the participants stopped receiving menopausal hormone therapy."
The researchers examined data from a sub-study of the CoLaus study, an ongoing prospective study to assess factors that affect the outcomes of cardiovascular disease. The participants in the sub-study, called the OsteoLaus cohort, were postmenopausal women between the ages of 50 and 80. The 1,086 participants were questioned about their current and past use of menopausal hormone therapy. All the women underwent dual-energy x-ray absorptiometry (DXA) scans to measure their body composition.
The women who were currently on menopausal hormone therapy exhibited significantly lower levels of abdominal fat tissue than women who had never received menopausal hormone therapy. The women going through menopausal hormone therapy also tended to have slightly lower total fat mass levels and body mass index measurements.
Among women who had previously used menopausal hormone therapy, the analysis found no residual effect on abdominal fat tissue. Regardless of how long women underwent menopausal hormone therapy and how much time had elapsed since they used MHT, the results suggested they experienced a rapid rebound in fat accumulation.
"Abdominal fat poses a risk for cardiovascular and bone health," Papadakis said. "When women stop menopausal hormone therapy, they need to be aware of the risk and ideally should increase their physical activity to combat the possibility of weight gain."
Other authors of the study include: Didier Hans, Peter Vollenweider, Gerard Waeber, Elena Gonzalez Rodriguez, Pedro Marques-Vidal and Olivier Lamy of CHUV, Lausanne University Hospital in Lausanne, Switzerland.
The OsteoLaus study was supported by research grants from Lausanne University Hospital and the Swiss National Science Foundation. The CoLaus study was supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and the Swiss National Science Foundation.
The study, "Menopausal Hormone Therapy is Associated with Reduced Total and Visceral Adiposity," will be published online, ahead of print.
Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world's oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.
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