Public Release: 

Spaceflight activates cell changes with implications for stem cell-based heart repair

Mary Ann Liebert, Inc./Genetic Engineering News

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Credit: Mary Ann Liebert, Inc., publishers

New Rochelle, NY, April 2, 2018-A new study of the effects of spaceflight on the development of heart cells identified changes in calcium signaling that could be used to develop stem cell-based therapies for cardiac repair. The impact of simulated microgravity and environmental factors on the International Space Station on cardiovascular progenitor cell development and signaling is reported in an upcoming special issue of Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Stem Cells and Development website until May 2, 2018.

The article "Spaceflight Activates Protein Kinase C Alpha Signaling and Modifies the Developmental Stage of Human Neonatal Cardiovascular Progenitor Cells" is coauthored by Johnathan Baio, Aida Martinez, Leonard Bailey, Nahidh Hasaniya, Michael Pecaut, and Mary Kearns-Jonker from Loma Linda University, CA. The researchers modeled the molecular changes seen at microgravity under normal gravity conditions and discussed the implications of these adaptive cellular responses for enhancing the potential of cardiovascular progenitor cells in regenerative medicine.

"This paper provides an important proof of concept for combining space- and ground-based experimental design and informs cardiac therapeutic development both for spaceflight and here on Earth," says Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.

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The study will appear in an upcoming special issue of Stem Cells and Development on Microgravity and Stem Cells.

About the Journal

Stem Cells and Development is an authoritative peer-reviewed journal published 24 times per year in print and online. The Journal is dedicated to communication and objective analysis of developments in the biology, characteristics, and therapeutic utility of stem cells, especially those of the hematopoietic system. A complete table of contents and free sample issue may be viewed on the Stem Cells and Development website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Cellular Reprogramming, Tissue Engineering, and Human Gene Therapy. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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