Public Release: 

Cross-species transmissibility of coronavirus

Proceedings of the National Academy of Sciences

Researchers report that the S protein of porcine deltacoronavirus (PDCoV) bound to a domain of the protein aminopeptidase N (APN), which is expressed on the surface of host cells and is highly conserved across animal species; expression of APN from pigs, humans, chickens, and cats facilitated PDCoV infection of cultured cells, suggesting a possible mechanism of PDCoV transmission from pigs to other species.

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Article #18-02879: "Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility," by Wentao Li et al.

MEDIA CONTACT: Linda J. Saif, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH; tel: 330-263-3744, 419-846-3011; e-mail: <saif.2@osu.edu>; Berend-Jan Bosch, Utrecht University, NETHERLANDS; tel: 31-30-2534195; e-mail: <b.j.bosch@uu.nl>

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