Researchers have developed a new type of sensor that acts like Velcro® for prostate cancer cells, sticking them to a modified frosted glass slide, like those used in science classes, so that they can be identified from blood samples. The low-cost method, reported in ACS Applied Materials & Interfaces, could help doctors better diagnose and monitor the disease.
In men with prostate cancer, some tumor cells exit the prostate gland and circulate in the blood. Detecting these cells could enable diagnosis at an earlier stage or help doctors assess whether treatment is effective. However, because circulating tumor cells are present in very small numbers, finding them can be a challenge. Previous sensors have been expensive and difficult to make. So Shudong Zhang and Shutao Wang wanted do develop a simpler, more cost-effective way to monitor prostate cancer cells in the blood.
The researchers based their device on frosted glass microscope slides, commonplace in high school science classes. The frosted area, which is used to hold and label the slide, is a sandblasted surface with tiny depressions. The researchers added a solution to the frosted slides that caused silica nanowires to grow on their surfaces, then they dangled antibodies that recognized prostate cancer cells from the nanowires. After getting captured by the antibodies, circulating tumor cells became trapped in the depressions on the slide and tangled up within the nanowires, similar to the interlocking surfaces of Velcro®. The team could then visualize the cancer cells with microscopy, and found that the device had a capture efficiency on par with other approaches, they say. When the researchers tested blood samples from prostate cancer patients, the devices detected as few as 10 tumor cells in 1 milliliter of blood.
The authors acknowledge funding from the National Natural Science Foundation, the Beijing Municipal Science & Technology Commission, the Top-Notch Young Talents Program of China and the Youth Innovation Promotion Association.
The abstract that accompanies this study is available here.
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