Public Release: 

Antibacterial glass ionomer cement with chlorhexidine-encapsulated mesoporous silica

International & American Associations for Dental Research

Alexandria, Va., USA - At the 96th General Session of the International Association for Dental Research (IADR), held in conjunction with the IADR Pan European Regional (PER) Congress, Huiyi Yan, Wuhan University, China gave an oral presentation titled "Antibacterial Glass Ionomer Cement With Chlorhexidine-Encapsulated Mesoporous Silica." The IADR/PER General Session & Exhibition is in London, England at the ExCeL London Convention Center from July 25-28, 2018.

Yan and co-authors aimed to establish a Chlorhexidine (CHX) delivery system based on expanded-pore mesoporous silica (CHX@pMSN), develop a new strategy that endows Glass Ionomer Cement (GIC) with anti-biofilm ability by appropriate addition of CHX@pMSN and then to evaluate the effects of CHX@pMSN on the mechanical properties of the modified GIC.

In the study, CHX@pMSN was added at three mass fractions (1%, 5%, and 10% (w/w)) to GIC powder as the experimental groups and pure GIC was set as the control group. The mechanical and anti-biofilm of S. mutans properties of GIC from each group were tested as well as mechanical properties such as compressive strength, surface hardness, elastic modulus, water sorption, and solubility and cumulative release of CHX.

The findings demonstrated that the anti-biofilm ability was significantly enhanced in all experimental groups compared with that in the control group. CHX was continuously released and anti-biofilm ability was maintained up to 30 days. In addition, the mechanical properties such as compressive strength, surface hardness, elastic modulus, water sorption and solubility were maintained compared with those in the control group.

Yan and co-authors concluded that adding 1% (w/w) CHX@pMSN to GIC led to notable anti-biofilm ability and had no adverse effect on the mechanical properties of this dental restorative material. This study proposes a new strategy for preventing secondary caries by using CHX@pMSN-modified GIC.

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This research was presented as part of the Dental Materials: Polymer-based Materials II oral session that took place on Wednesday, July 25 from 1:30 p.m. - 3 p.m. at the ExCeL London Convention Center in London, England.

About the International Association for Dental Research

The International Association for Dental Research (IADR) is a nonprofit organization with over 10,800 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge for the improvement of oral health worldwide, (2) supporting and representing the oral health research community, and (3) facilitating the communication and application of research findings. To learn more, visit http://www.iadr.org.

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