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Tree shrews can tolerate hot peppers: Mutation in pain receptor makes peppery plant palatable

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IMAGE: An evolutionary adaptation allows Chinese tree shrews to tolerate the pain of hot peppers. view more 

Credit: Thomas Foley on Unsplash

Almost all mammals avoid eating chili peppers and other "hot" foods, because of the pain they induce. But not the tree shrew, according to a study publishing July 12 in the open-access journal PLOS Biology by Yalan Han of the Kunming Institute of Zoology in China, and colleagues. The researchers found that this close relative of primates is unaffected by the active ingredient in chili peppers due to a subtle mutation in the receptor that detects it. They speculate that this is an evolutionary adaptation to enable tree shrews to cope with a peppery plant that makes up part of their diet.

Capsaicinoids, including the capsaicin found in chili peppers, are chemicals that deter animals from eating them. They act by triggering the activation of TRPV1, an ion channel found on the surface of pain-sensitive cells in the tongue and elsewhere. TRPV1's normal job is to alert animal to the presence of harmful heat, which is why capsaicinoids induce a sharp burning sensation. While humans may develop a tolerance and even a liking for capsaicinoids, most animals avoid feeding on plants that contain them.

The authors observed that Chinese tree shrews (Tupaia belangeri chinensis) actively fed on chili peppers, and, in contrast with mice, did not reduce their food intake as the concentration of capsaicin increased. They found that while the levels of TRPV1 in mice and tree shrews were similar, and both mammals were similarly responsive to other painful stimuli, the TRPV1 ion channel in the tree shrew was much less responsive to capsaicin. The authors then revealed the reason for this; TRPV1 proteins of mice and tree shrews differed by a single amino acid in the binding pocket for capsaicin, a mutation that the researchers found reduced the binding ability, and thus pain-inducing potential, of capsaicin in the tree shrew's form of the protein.

While chili peppers themselves do not grow in the tree shrew's environment, a plant that produces abundant capsaicinoids, Piper boehmeriaefolium, does, and is an important food source for the tree shrew. The ability to feed on this plant while most other species avoid it, the authors suggest, was potentially an important driver for the spread of the TRPV1 mutation through the tree shrew population over time.

"We propose that this mutation is an evolutionary adaptation that enabled the tree shrew to acquire tolerance for capsaicinoids, thus widening the range of its diet for better survival," Han says.

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In your coverage please use this URL to provide access to the freely available article in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/ journal.pbio.2004921

Citation: Han Y, Li B, Yin T-T, Xu C, Ombati R, Luo L, et al. (2018) Molecular mechanism of the tree shrew's insensitivity to spiciness. PLoS Biol 16(7): e2004921. https://doi.org/10.1371/journal.pbio.2004921

Image Caption: An evolutionary adaptation allows Chinese tree shrews to tolerate the pain of hot peppers.

Image Credit: Thomas Foley on Unsplash

Funding: National Science Foundation of China http://www.nsfc.gov.cn/ (grant number 21761142, 31640071, 31770835). Grant number 21761142 to RL; Grant number 31640071 and 31770835 to SY. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Chinese Academy of Sciences http://www.cas.cn/ (grant number 21761142002, SAJC201606, "Light of West China" Program and Youth Innovation Promotion Association). Grant number 21761142002 and SAJC201606 to RL; "Light of West China" Program to SY; Youth Innovation Promotion Association to SY and GDW. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Yunnan Province http://www.ynstc.gov.cn/ (grant number 2015HA023, 2017FB037). Grant number 2015HA023 to RL; Grant number 2017FB037 to SY. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Central Organization Department http://1000plan.org/qrjh/article/69239 (grant number The Young Thousand Talents Plan of China). The Young Thousand Talents Plan of China to FY. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

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