image: In green -- the endothelium. In orange -- stem cells adding to the blood vessel's lining. view more
Credit: BHF/Christiana Ruhrberg
A unique source of stem cells in blood helps to build blood vessels in the growing embryo according to new research published in Nature and part-funded by the British Heart Foundation.
This finding changes scientific understanding of how blood vessels are made and brings scientists one step closer to using stem cells to grow new blood vessels and repair damaged ones.
Growing and repairing blood vessels is a major goal in treating heart and circulatory diseases, where vessels become damaged, for example - coronary heart disease and peripheral arterial disease.
Until now scientists thought that new blood vessels in the embryo only grew when existing endothelial cells - important cells which line all blood vessels - divided. The new research from UCL (University College London) shows that stem cells in the bloodstream can develop into endothelial cells and add to the vessel wall.
Stem cells are cells that can differentiate into mature cell types. For decades researchers have been searching for stem cells in the blood that can develop into endothelial cells because of their potential in regenerative medicine. So far, scientists have disagreed about what such 'endothelial progenitor cells' are, what they look like, and whether they truly exist in the blood.
This study provides important new evidence that such a stem cell exists in the blood stream of developing embryos. A next step will be to determine whether these cells can add to the lining of blood vessels throughout life, and tracking them down in humans.
The researchers used fluorescent tags to follow the fate of the stem cells, called erythromyeloid progenitors (EMPs). These cells were already known to develop into red blood cells and certain types of immune cells. EMP stem cells grown in a dish developed into endothelial cells as well as red blood cells and immune cells. The EMP stem cells also developed into endothelial cells in mice that were naturally growing in their mother's womb, and they continued to line blood vessels into adulthood.
Methods need to be developed in order to track these elusive cells down in humans. More research is also needed to determine if the endothelial cells that come from EMPs have their own unique function and just how they can be used in regenerative medicine.
Professor Christiana Ruhrberg from the UCL Institute of Ophthalmology and senior author of the study said:
"Until now, scientists thought EMPs only formed red blood and immune system cells in the foetus. To find that they also generate endothelial cells for growing new blood vessels in the foetus was unexpected and is hugely exciting."
Professor Metin Avkiran, Associate Medical Director at the British Heart Foundation said:
"Using stem cells to treat patients with heart and circulatory disease has huge potential. But taking positive findings from the lab to patients has often been very challenging.
"These scientists have looked at how blood vessels develop in the embryo, and their findings have shed important new light on our understanding of the origin of growing blood vessels."
"Getting these fundamentals right is essential for finding stem cell treatments which will work in patients. These findings could pave the way to new discoveries in regenerative medicine and allow scientists in the future to grow new blood vessels and repair those that are damaged in many forms of heart and circulatory disease."
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This research was funded by research grants from the British Heart Foundation, Wellcome Trust and Medical Research Council.
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Notes to editors
1. Paper available on request
2. Image available on request
British Heart Foundation Heart and circulatory diseases kill 1 in 4 people in the UK. For over 50 years we've pioneered research that's transformed the lives of people living with heart and circulatory conditions. Our work has been central to the discoveries of vital treatments that are changing the fight against heart disease. But so many people still need our help. From babies born with life-threatening heart problems to the many Mums, Dads and Grandparents who survive a heart attack and endure the daily battles of heart failure. Every pound raised, minute of your time and donation to our shops will help make a difference to people's lives.
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About UCL (University College London)
UCL was founded in 1826. We were the first English university established after Oxford and Cambridge, the first to open up university education to those previously excluded from it, and the first to provide systematic teaching of law, architecture and medicine. We are among the world's top universities, as reflected by performance in a range of international rankings and tables. UCL currently has over 39,000 students from 150 countries and over 12,500 staff. Our annual income is more than £1 billion.
Journal
Nature