Public Release: 

REDUCE-IT reveals high dose of pure EPA in omega-3 drug cuts risk of cardiovascular events

Clinical trial of icosapent ethyl finds 25 percent reduction in cardiovascular events among at-risk patients

Brigham and Women's Hospital

Boston, MA -- Results released today from a major clinical trial may have direct implications for patients who remain at increased cardiovascular risk despite taking statin therapy. The trial, led by investigators at Brigham and Women's Hospital, has found that a drug developed by Amarin Corporation plc, icosapent ethyl - a pure and stable form of the omega-3 acid known as EPA - reduced the risk of death due to cardiovascular causes, heart attack, and stroke in this population. The main results of the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT), sponsored by Amarin, were presented by Deepak L. Bhatt, MD, MPH, executive director of Interventional Cardiovascular Programs at the Brigham and professor of medicine at Harvard Medical School, at the American Heart Association Scientific Sessions 2018 and published simultaneously in the New England Journal of Medicine.

"We are reporting a remarkable degree of risk reduction," said Bhatt. "We've found that icosapent ethyl reduced the risk of important cardiovascular events by 25 percent, including a 20 percent reduction in death due to cardiovascular causes, a 31 percent reduction in heart attack, and a 28 percent reduction in stroke. The REDUCE-IT trial sets a new standard of care for patients who have elevated triglycerides and are at increased cardiovascular risk despite statin therapy. This may be the biggest development in cardiovascular prevention since statins."

Icosapent ethyl is a prescription medication approved to reduce triglyceride levels in patients with very high triglycerides. Studies have suggested that icosapent ethyl may have additional attributes such as anti-inflammatory and cell membrane-stabilizing properties that may also contribute to reducing cardiovascular risk.

REDUCE-IT included more than 8,000 patients with well-controlled LDL-cholesterol who were taking statins to prevent a first or subsequent cardiovascular event. Approximately 70 percent of patients in the study had established atherosclerosis and the rest had diabetes plus at least one other cardiovascular risk factor. Patients had triglyceride levels that ranged from borderline high (135 mg/dL) to near very high (499 mg/dL). Patients were randomized to receive either 2 grams icosapent ethyl twice daily or a placebo and were followed for an average of approximately five years.

Hospitalization for chest pain, heart attack, procedures for coronary artery disease such as stenting, stroke, and cardiovascular death occurred in 17.2 percent of patients taking icosapent ethyl versus 22 percent of patients taking the placebo - an absolute risk reduction of 4.8 percent. The team also reported a significant 26 percent reduction in the trial's key secondary endpoint, which included cardiovascular death, nonfatal heart attack, or nonfatal stroke (11.2 percent for the icosapent ethyl group vs. 14.8 percent for the placebo group).

The researchers note that cardiovascular benefits appeared similar irrespective of patients' baseline levels of triglycerides or levels achieved after one year, suggesting that the cardiovascular risk reduction was not solely tied to achieving a more normal triglyceride level.

"The exact mechanisms responsible for the impressive benefits seen in the REDUCE-IT trial are not currently known," said Bhatt. "The significant effects on very different endpoints, such as cardiac arrest and stroke, suggest that this drug may have multiple biological mechanisms of action that have not been shown for any other therapy and cannot be generalized to other omega-3 products."


REDUCE-IT was sponsored by Amarin. Brigham and Women's Hospital receives research funding from Amarin for the work Bhatt did as the trial chair and as the international principal investigator. Disclosure forms provided by the authors are available with the full text of the article at

Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare. BWH has more than 4.2 million annual patient visits and nearly 46,000 inpatient stays, is the largest birthing center in Massachusetts and employs nearly 16,000 people. The Brigham's medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in patient care, quality improvement and patient safety initiatives, and its dedication to research, innovation, community engagement and educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Brigham Research Institute (BRI), BWH is an international leader in basic, clinical and translational research on human diseases, more than 3,000 researchers, including physician-investigators and renowned biomedical scientists and faculty supported by nearly $666 million in funding. For the last 25 years, BWH ranked second in research funding from the National Institutes of Health (NIH) among independent hospitals. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative as well as the TIMI Study Group, one of the premier cardiovascular clinical trials groups. For more information, resources and to follow us on social media, please visit BWH's online newsroom.

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