image: In this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. view more
Credit: Bentham Science Publisher, Claudio Cabello-Verrugio
The innate immune system comprises of various soluble factors that provide the first line of defense against pathogens. Transforming Growth Factor type Beta 1 (TGF-β1) is one such soluble factor that also regulates skeletal muscle function, and it one of the most studied factors. TGF-Beta 1 is a potent modulator of immune and glial cell functions. It is known to have a play in to cardiac fibrosis and muscle atrophy. It also regulates the activity and function of satellite cells that inhibits myo-genesis.
In this review, researchers present different types of mechanisms and cellular targets which are involved with the effects of TGF-Beta 1 muscles, such as pothological the processes like fibrosis, atrophy and inhibition of regeneration. Furthermore, the reviewers also present an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle.
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The article is Open Access till 31st January, 2019. To obtain the article please visit http://www.eurekaselect.com/157258
Journal
Current Protein and Peptide Science