Public Release: 

Central role of transforming growth factor type beta 1 in skeletal muscle dysfunctions

This article by Dr. Claudio Cabello-Verrugio et al. is published in Current Protein & Peptide Science, Volume 19, Issue 12, 2018

Bentham Science Publishers


IMAGE: In this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as... view more 

Credit: Bentham Science Publisher, Claudio Cabello-Verrugio

The innate immune system comprises of various soluble factors that provide the first line of defense against pathogens. Transforming Growth Factor type Beta 1 (TGF-β1) is one such soluble factor that also regulates skeletal muscle function, and it one of the most studied factors. TGF-Beta 1 is a potent modulator of immune and glial cell functions. It is known to have a play in to cardiac fibrosis and muscle atrophy. It also regulates the activity and function of satellite cells that inhibits myo-genesis.

In this review, researchers present different types of mechanisms and cellular targets which are involved with the effects of TGF-Beta 1 muscles, such as pothological the processes like fibrosis, atrophy and inhibition of regeneration. Furthermore, the reviewers also present an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle.


The article is Open Access till 31st January, 2019. To obtain the article please visit

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.