Researchers report a modification to the traditional procedure for influenza virus vaccine production that removes the complex glycans normally attached to the viral hemagglutinin protein; the resulting vaccine induced a broader immune response against multiple virus strains in mice than a traditional vaccine, leading to better cross-strain protection and enhanced survival compared with the traditional vaccine and potentially reducing the need for annual influenza virus reformulation.
Article #18-19197: "Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections," by Yung-Chieh Tseng et al.
MEDIA CONTACT: Chi-Huey Wong, Academia Sinica, Taipei, TAIWAN; tel: +886-2-2789-9929; e-mail: chwong@gate.sinica.edu.tw
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