Potentially lethal heart conditions may become easier to spot and may lead to improvements in prevention and treatment thanks to innovative new software that measures electrical activity in the organ.
The heart's pumping ability is controlled by electrical activity that triggers the heart muscle cells to contract and relax. In certain heart diseases such as arrhythmia, the organ's electrical activity is affected.
Cardiac researchers can already record and analyse the heart's electrical behaviour using optical and electrode mapping, but widespread use of these technologies is limited by a lack of appropriate software.
Computer and cardiovascular experts at the University of Birmingham have worked with counterparts in the UK, Netherlands and Australia to develop ElectroMap - a new open-source software for processing, analysis and mapping complex cardiac data.
Led by researchers from the School of Computer Science and the Institute of Cardiovascular Sciences, at the University of Birmingham, the international team has published its findings in Scientific Reports.
Dr Kashif Rajpoot, Senior Lecturer and Programme Director for Computer Science at the University of Birmingham Dubai, commented: "We believe that ElectroMap will accelerate innovative cardiac research and lead to wider use of mapping technologies that help to prevent the incidence of arrhythmia.
"This is a robustly validated open-source flexible tool for processing and by using novel data analysis strategies we have developed, this software will provide a deeper understanding of heart diseases, particularly the mechanisms underpinning potentially lethal arrhythmia."
The incidence and prevalence of cardiac disease continues to increase every year, but improvements in prevention and treatment require better understanding of electrical behaviour across the heart.
Data on this behaviour can be gathered using electrocardiogram tests, but more recently, optical mapping has allowed wider measurement of cardiovascular activity in greater detail. Insights from optical mapping experiments have given researchers a better understanding of complex arrhythmias and electrical behaviour in heart disease.
"Increased availability of optical mapping hardware in the laboratory has led to expansion of this technology, but further uptake and wider application is hindered by limitations with respect to data processing and analysis," said Dr Davor Pavlovic - lead contributor from the University of Birmingham's Institute of Cardiovascular Sciences. "The new software can detect, map and analyse arrhythmic phenomena for in silico, in cellulo, animal model and in vivo patient data."
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Notes for editors
The University of Birmingham is ranked amongst the world's top 100 institutions, its work brings people from across the world to Birmingham, including researchers and teachers and more than 6,500 international students from over 150 countries.
Scientists at the Universities of Birmingham, Leicester, Amsterdam and Melbourne published their research paper 'High-throughput open-source software for analysis and mapping of cardiac electrophysiology' in Nature Scientific Reports. The paper is accessible at: https:/
The paper was written by Christopher O'Shea, Andrew P.Holmes, Ting Y.Yu, James Winter, Simon P.Wells, Joao Correia, Bastiaan J. Boukens, Joris R.De Groot, Gavin S.Chu, Xin Li, G.Andre Ng, Paulus Kirchhof, Larissa Fabritz, Kashif Rajpoot and Davor Pavlovic.